This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
PLAP RMab
catalog :
MBS370099
quantity :
3 ml
price :
175 USD
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
EP194
reactivity :
human
product information
catalog number :
MBS370099
products type :
Antibody
products full name :
PLAP RMab
products short name :
PLAP
products name syn :
PLAP RMab
other names :
alkaline phosphatase, placental type preproprotein; Alkaline phosphatase, placental type; alkaline phosphatase, placental type; PLAP-1; Regan isozyme; OTTHUMP00000164354; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme; alkaline phosphatase, placental; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1
products gene name :
PLAP
other gene names :
ALPP; ALPP; ALP; PALP; PLAP; FLJ61142; PLAP
uniprot entry name :
PPB1_HUMAN
clonality :
Monoclonal
isotype :
IgG
clone :
EP194
host :
Rabbit
form :
PLAP is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
storage stability :
Store at 2 to 8 degree C in the dark.
other info1 :
Control: Placenta. Localization: Cytoplasmic
other info2 :
Reactivity Note: Paraffin, Frozen
products description :
Placental Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal mature human placenta, Seminomas of testis and Ovarian Carcinomas. Detection of alkaline phosphatase in serum is a marker for Ovarian and Testicular Cancer. This antibody reacts with a membrane-bound isoenzyme of placental alkaline phosphatase occurring in the placenta during the 3rd trimester of gestation.
ncbi gi num :
94721246
ncbi acc num :
NP_001623.3
ncbi gb acc num :
NM_001632.3
uniprot acc num :
P05187
ncbi mol weight :
52746 Da
ncbi pathways :
Folate Biosynthesis Pathway 83018!!Folate Biosynthesis Pathway 404!!Metabolic Pathways 132956
ncbi summary :
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq]
uniprot summary :
Catalytic activity: A phosphate monoester + H2O = an alcohol + phosphate. Cofactor: Binds 1 magnesium ion. By similarity.Binds 2 zinc ions. Subunit structure: Homodimer. Subcellular location: Cell membrane; Lipid-anchor GPI-anchor Ref.10 Ref.11. Polymorphism: Placental ALP is highly polymorphic, there are at least three common alleles. Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney). Sequence similarities: Belongs to the alkaline phosphatase family. Sequence caution: The sequence AAA51708.1 differs from that shown. Reason: Erroneous initiation.
size :
3 ml
price :
175 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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