This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
Interleukin-1 Receptor Antagonist
catalog :
MBS340186
quantity :
1 ml
price :
350 USD
clonality :
polyclonal
host :
sheep
conjugate :
nonconjugated
reactivity :
human
product information
catalog number :
MBS340186
products type :
Antibody
products full name :
Interleukin-1 Receptor Antagonist
products short name :
Interleukin-1 Receptor Antagonist
products name syn :
Anti - INTERLEUKIN 1 RECEPTOR, ANTAGONIST (IL-1Ra); INTERLEUKIN 1 RECEPTOR ANTAGONIST
other names :
interleukin-1 receptor antagonist; Interleukin-1 receptor antagonist protein; interleukin-1 receptor antagonist protein; IL1 inhibitor; IL1RN (IL1F3); OTTHUMP00000162022; OTTHUMP00000162023; OTTHUMP00000162024; OTTHUMP00000203731; type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); interleukin 1 receptor antagonist; ICIL-1RA; IL1 inhibitor
products gene name :
IL-1Ra
other gene names :
IL1RN; IL1RN; DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA; MGC10430; IL1F3; IL1RA
uniprot entry name :
IL1RA_HUMAN
clonality :
Polyclonal
host :
Sheep
form :
Ig fraction, liquid
storage stability :
Store at -20 degree C. Avoid repeated freeze/thaw cycles.
other info1 :
Immunogen: Recombinant Human IL-1Ra
other info2 :
Buffer: 20mM Phosphate, 150mM Sodium Chloride, pH 7.2. Preservative: 0.09% Sodium Azide
ncbi gi num :
32577
ncbi acc num :
CAA36262.1
uniprot acc num :
P18510
ncbi mol weight :
20,055 Da
ncbi pathways :
Cytokine Signaling In Immune System Pathway 366171!!IL-1 Signaling Pathway 198908!!IL1-mediated Signaling Events Pathway 137944!!Immune System Pathway 106386!!Interleukin-1 Signaling Pathway 160141!!Signaling By Interleukins Pathway 160140
ncbi summary :
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
uniprot summary :
Function: Inhibits the activity of IL-1 by binding to its receptor. Has no IL-1 like activity. Subcellular location: Isoform 1: Secreted. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm. Tissue specificity: The intracellular form of IL1RN is predominantly expressed in epithelial cells. Involvement in disease: Genetic variation in IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4) [. MIM:612628]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.Defects in IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) [. MIM:612852]; also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis (bone inflammation in multiple places), periostitis (inflammation of the membrane surrounding the bones), and pustulosis (due to skin inflammation) from birth. Ref.18. Pharmaceutical use: Available under the name Kineret (Amgen). Used for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis.
size :
1 ml
price :
350 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!