MyBioSource

antibody

MAb to PSMA

MBS312806

1 mg

475 USD

monoclonal

mouse

MBS312806

Antibody

MAb to PSMA

Prostate Specific Membrane Antigen

Prostate Specific Membrane Antigen (PSMA)

prostate- specific membrane antigen; Glutamate carboxypeptidase 2; glutamate carboxypeptidase 2; NAALADase I; OTTHUMP00000233840; OTTHUMP00000233841; OTTHUMP00000233843; OTTHUMP00000233844; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; prostate specific membrane antigen variant F; pteroylpoly-gamma-glutamate carboxypeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I; folate hydrolase (prostate-specific membrane antigen) 1; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; FGCP; Glutamate carboxypeptidase II; GCPII; Membrane glutamate carboxypeptidase; mGCP; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen; PSM; PSMA; Pteroylpoly-gamma-glutamate carboxypeptidase

PSMA

FOLH1; FOLH1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; FOLH; NAALAD1; PSM; PSMA

FOLH1_HUMAN

Monoclonal

IgG2a

B793M

Host: Mouse. Source: Ascites

Human

750

Prostate Specific Membrane Antigen (PSMA)

>95% pure (SDS-PAGE). Protein G chromatography

Purified, Liquid

Store at 2-8 degree C.

ELISA

Suitable for use in indirect ELISA.

Host Animal: Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from BALB/c mice. Immunogen: Recombinant C-terminal PSMA conjugated with APP. Species Specificity: C-terminal human prostate specific membrane antigen. Affinity Constant: Not determined

Buffer: PBS, pH 7.4. Preservative: NaN3 (0.1% Sodium azide). Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.

Monoclonal Antibodies for Cancer Research

MAb to PSMA. Monoclonal Antibody to Human Prostate Specific Membrane Antigen (PSMA)

190664

Q04609

84,331 Da

One Carbon Metabolism Pathway 198756!!Vitamin Digestion And Absorption Pathway 199556!!Vitamin Digestion And Absorption Pathway 199538

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq]

Function: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. Catalytic activity: Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates. Cofactor: Binds 2 zinc ions per subunit. Required for NAALADase activity. Ref.27. Enzyme regulation: The NAALADase activity is inhibited by beta-NAAG, quisqualic acid, 2-(phosphonomethyl) pentanedioic acid (PMPA) and EDTA. Activated by cobalt. Ref.29. Subunit structure: Homodimer. Ref.27. Subcellular location: Cell membrane; Single-pass type II membrane protein Ref.17. Isoform PSMA': Cytoplasm Ref.17. Tissue specificity: Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-2 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer. Ref.15 Ref.24 Ref.25 Ref.26. Induction: In the prostate, up-regulated in response to androgen deprivation. Ref.29. Domain: The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal. Ref.20. Post-translational modification: The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis.The N-terminus is blocked. Polymorphism: Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease, neural tube defects, and cognitive deficits. Miscellaneous: PSMA is used as a diagnostic and prognostic indicator of prostate cancer, and as a possible marker for various neurological disorders such as schizophrenia, Alzheimer disease and Huntington disease. Sequence similarities: Belongs to the peptidase M28 family. M28B subfamily. Biophysicochemical propertiespH dependence:Stable at pH greater than 6.5. Sequence caution: The sequence AAF31167.1 differs from that shown. Reason: Erroneous gene model prediction.

1 mg

475 USD