product summary
request information :
company name :
MyBioSource
product type :
antibody
product name :
Rabbit Anti-Human MEF-2 Polyclonal Antibody
catalog :
MBS301392
quantity :
0.1 ml
price :
170 USD
clonality :
polyclonal
host :
rabbit
reactivity :
rat, dog, chicken, mouse, human
application :
immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS301392
products type :
Antibody
products full name :
Rabbit Anti-Human MEF-2 Polyclonal Antibody
products short name :
MEF-2
other names :
myocyte-specific enhancer factor 2A isoform 2; Myocyte-specific enhancer factor 2A; myocyte-specific enhancer factor 2A; MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A); serum response factor-like protein 1; myocyte enhancer factor 2A; Serum response factor-like protein 1
products gene name :
MEF-2
other gene names :
MEF2A; MEF2A; mef2; ADCAD1; RSRFC4; RSRFC9; MEF2
uniprot entry name :
MEF2A_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human. Predicted Reactivity: Bovine, Chicken, Dog, Frog, Mouse, Pig, Rabbit, Rat
sequence length :
497
form :
0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
storage stability :
Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
tested application :
Immunohistochemistry (IHC) Paraffin
app notes :
Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: 1:100. IHC Positive Control: Brain
other info2 :
Immunogen: Synthetic peptide corresponding to aa 487-507 of human MEF-2. Control Tissue: Brain. Cellular Localization: Nucleus. Entrez Gene Code: 4205. Pathway: Transcriptional Regulators
products description :
The myocyte enhancer factors-2 (MEF-2) family of transcription factors associate with a variety of co-repressors or co-activators to regulate development and function of T cells, neuronal cells, and muscle cells. Four distinct family members arise from alternatively spliced transcripts, termed MEF-2A, MEF-2B, MEF-2C, and MEF-2D. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the 4 transcripts implies functional distinction for each during embryogenesis and development.
ncbi gi num :
195972801
ncbi acc num :
NP_001124398.1
ncbi gb acc num :
NM_001130926.1
ncbi mol weight :
55 kDa
ncbi pathways :
Activated TLR4 Signalling Pathway 106400!!Adipogenesis Pathway 198832!!BDNF Signaling Pathway 712093!!CDO In Myogenesis Pathway 160998!!Developmental Biology Pathway 477129!!ERK/MAPK Targets Pathway 106482!!Energy Metabolism Pathway 198907!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!MAP Kinase Activation In TLR Cascade Pathway 160135
ncbi summary :
The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
size :
0.1 ml
price :
170 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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