Rabbit Anti-Human MEF-2 Polyclonal Antibody | MyBioSource MBS300166 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Anti-Human MEF-2 Polyclonal Antibody

catalog :

MBS300166

quantity :

7 ml

price :

280 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat, dog, chicken

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS300166

products type :

Antibody

products full name :

Rabbit Anti-Human MEF-2 Polyclonal Antibody

products short name :

MEF-2

other names :

myocyte-specific enhancer factor 2A isoform 2; Myocyte-specific enhancer factor 2A; myocyte-specific enhancer factor 2A; MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A); serum response factor-like protein 1; myocyte enhancer factor 2A; Serum response factor-like protein 1

products gene name :

MEF-2

other gene names :

MEF2A; MEF2A; mef2; ADCAD1; RSRFC4; RSRFC9; MEF2

uniprot entry name :

MEF2A_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human. Predicted Reactivity: Bovine, Chicken, Dog, Frog, Mouse, Pig, Rabbit, Rat

sequence length :

497

form :

7.0 ml pre-diluted immunogen affinity purified rabbit polyclonal antibody in TBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

storage stability :

Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.

tested application :

Immunohistochemistry (IHC) Paraffin

app notes :

Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: Ready To Use. IHC Positive Control: Brain

other info2 :

Immunogen: Synthetic peptide corresponding to aa 487-507 of human MEF-2. Control Tissue: Brain. Cellular Localization: Nucleus. Entrez Gene Code: 4205. Pathway: Transcriptional Regulators

products description :

The myocyte enhancer factors-2 (MEF-2) family of transcription factors associate with a variety of co-repressors or co-activators to regulate development and function of T cells, neuronal cells, and muscle cells. Four distinct family members arise from alternatively spliced transcripts, termed MEF-2A, MEF-2B, MEF-2C, and MEF-2D. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the 4 transcripts implies functional distinction for each during embryogenesis and development.

ncbi gi num :

195972801

ncbi acc num :

NP_001124398.1

ncbi gb acc num :

NM_001130926.1

ncbi mol weight :

55 kDa

ncbi pathways :

Activated TLR4 Signalling Pathway 106400!!Adipogenesis Pathway 198832!!BDNF Signaling Pathway 712093!!CDO In Myogenesis Pathway 160998!!Developmental Biology Pathway 477129!!ERK/MAPK Targets Pathway 106482!!Energy Metabolism Pathway 198907!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!MAP Kinase Activation In TLR Cascade Pathway 160135

ncbi summary :

The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

size :

7 ml

price :

280 USD