GIT2 antibody, Internal | MyBioSource MBS270292 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

GIT2 antibody, Internal

catalog :

MBS270292

quantity :

0.1 ml

price :

360 USD

clonality :

polyclonal

host :

rabbit

reactivity :

western clawed frog, human, cow

application :

western blot, immunocytochemistry

product information

catalog number :

MBS270292

products type :

Antibody

products full name :

GIT2 antibody, Internal

products short name :

GIT2

products name syn :

G protein-coupled receptor kinase interacting ArfGAP 2; CAT-2 antibody; CAT2 antibody; DKFZp686G01261 antibody; KIAA0148 antibody; MGC760 antibody; GIT2 antibody; "cool-associated; tyrosine phosphorylated protein 2 antibody"; ARF GTPase-activating protein GIT2 antibody; G protein-coupled receptor kinase-interactor 2 antibody; ARF GAP GIT2 antibody; GRK-interacting protein 2 antibody; cool-interacting tyrosine-phosphorylated protein 2 antibody; G protein-coupled receptor kinase interacting ArfGAP 2 antibody

other names :

ARF GTPase-activating protein GIT2 isoform 5; G protein-coupled receptor kinase-interactor 2 isoform 4; ARF GTPase-activating protein GIT2; ARF GAP GIT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2; cool-associated, tyrosine phosphorylated protein 2; cool-interacting tyrosine-phosphorylated protein 2; G protein-coupled receptor kinase interacting ArfGAP 2; G protein-coupled receptor kinase-interactor 2 isoform 4

products gene name :

GIT2

other gene names :

GIT2; GIT2; CAT2; CAT-2

uniprot entry name :

Q6FI58_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human. Predicted Reactivity: Rat (93%), Xenopus laevis (87%), Bovine (94%), Xenopus tropicalis (87%)

sequence length :

729

purity :

Purified by antigen-affinity chromatography.

form :

Liquid

concentration :

1 mg/ml

storage stability :

Keep as concentrated solution. Aliquot and store at -20 degree C or below. Avoid multiple freeze-thaw cycles.

tested application :

Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)

app notes :

ICC/IF: 1:100-1:1000. Western blot: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher.

other info1 :

Storage Buffer: 1XPBS, 40% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. Predicted Target Size: 85 kDa. Positive Controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji

other info2 :

Immunogen: Recombinant fragment corresponding to a region within amino acids 234 and 456 of GIT2 (Uniprot ID#Q14161). Antigen Species: Human

products description :

Background: This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq]. Product Description: Rabbit Polyclonal antibody to GIT2 (G protein-coupled receptor kinase interacting ArfGAP 2)

ncbi gi num :

206725422

ncbi acc num :

NP_001128686

ncbi gb acc num :

NM_001135214

uniprot acc num :

Q6FI58

ncbi mol weight :

52,577 Da

ncbi pathways :

Endocytosis Pathway 102279!!Endocytosis Pathway 102181!!Integrin-mediated Cell Adhesion Pathway 198816!!Signaling Events Mediated By Focal Adhesion Kinase Pathway 169348

ncbi summary :

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]

size :

0.1 ml

price :

360 USD