Rabbit Polyclonal to Human PDK1 / PDPK1 | MyBioSource MBS241039 product information

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product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human PDK1 / PDPK1

catalog :

MBS241039

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, enzyme immunoassay

product information

catalog number :

MBS241039

products type :

Antibody

products full name :

Rabbit Polyclonal to Human PDK1 / PDPK1

products short name :

PDK1 / PDPK1

products name syn :

Anti-PDK1 / PDPK1 Antibody (phospho-Ser241) IHC-plus; PDPK1; HPDK1; PkB kinase like gene 1; PkB-like 1; Pdk-1; PkB kinase; PRO0461; Human PDK1; PDPK1

other names :

3-phosphoinositide-dependent protein kinase 1 isoform 1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 1; PkB kinase like gene 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; 3-phosphoinositide dependent protein kinase 1

products gene name :

PDK1

products gene name syn :

PDPK1

other gene names :

PDPK1; PDPK1; PDK1; PDPK2; PDPK2P; PRO0461; PDK1; hPDK1

uniprot entry name :

PDPK1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

556

specificity :

Amino acids 236 to 248 with pSER 241 of human PDPK1

purity :

Protein G Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

app notes :

ELISA (1:000 - 1:1000), IHC-P (5 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human PDPK1.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: PDK1 / PDPK1 antibody was raised against synthetic peptide from human PDPK1. Antigen Modification: pSer241

products categories :

Family: Protein Kinase. Subfamily: RAC/AKT

ncbi gi num :

4505695

ncbi acc num :

NP_002604.1

ncbi gb acc num :

NM_002613.4

uniprot acc num :

O15530

ncbi mol weight :

50,838 Da

ncbi pathways :

AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Activation Of PKB Pathway (106436); Adaptive Immune System Pathway (366160); Aldosterone-regulated Sodium Reabsorption Pathway (130626); Aldosterone-regulated Sodium Reabsorption Pathway (130590); B Cell Receptor Signaling Pathway (198909); BCR Signaling Pathway (138058); BDNF Signaling Pathway (712093)

uniprot summary :

PDK1: an AGC kinase of the PKB family that contains a PH domain. Involved in a wide variety of processes including cell proliferation, differentiation and apoptosis. Autophosphorylation in the activation loop is necessary for activity. Phosphorylates and activates kinases including Akt, PKC isozymes, p70 S6K and RSK. Three alternatively-spliced isoforms have been described. Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Nuclear receptor co-regulator; EC 2.7.11.1; AGC group; PKB family. Chromosomal Location of Human Ortholog: 16p13.3. Cellular Component: nucleoplasm; focal adhesion; cell projection; membrane; cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; cytosol. Molecular Function: protein serine/threonine kinase activity; protein binding; phospholipase binding; 3-phosphoinositide-dependent protein kinase activity; kinase activity; protein kinase binding; insulin receptor binding; ATP binding; phospholipase activator activity. Biological Process: regulation of mast cell degranulation; focal adhesion formation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; T cell receptor signaling pathway; protein amino acid phosphorylation; synaptic transmission; regulation of transcription, DNA-dependent; regulation of I-kappaB kinase/NF-kappaB cascade; epidermal growth factor receptor signaling pathway; platelet activation; cell migration; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; transcription, DNA-dependent; activation of protein kinase B; peptidyl-threonine phosphorylation; calcium-mediated signaling; hyperosmotic response; cellular response to insulin stimulus; T cell costimulation; insulin receptor signaling pathway; negative regulation of toll-like receptor signaling pathway; innate immune response; negative regulation of protein kinase activity; positive regulation of release of sequestered calcium ion into cytosol; actin cytoskeleton organization and biogenesis; vascular endothelial growth factor receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; blood coagulation

size1 :

0.05 mg

price1 :

495 USD