Rabbit Polyclonal to Human ABCB1 / MDR1 / P Glycoprotein | MyBioSource MBS240173 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human ABCB1 / MDR1 / P Glycoprotein

catalog :

MBS240173

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS240173

products type :

Antibody

products full name :

Rabbit Polyclonal to Human ABCB1 / MDR1 / P Glycoprotein

products short name :

ABCB1 / MDR1 / P Glycoprotein

products name syn :

Anti-ABCB1 / MDR1 / P Glycoprotein Antibody (Cytoplasmic Domain) IHC-plus; ABCB1; ABC20; Abcb1b; CLCS; Colchicin sensitivity; CD243; Doxorubicin resistance; IBD13; gp170; MDR1; Multidrug resistance protein 1; P glycoprotein; P-glycoprotein 1; P-GP; CD243 antigen; PGY1; Human ABCB1; MDR1; P Glycoprotein

other names :

multidrug resistance protein 1; Multidrug resistance protein 1; multidrug resistance protein 1; P-glycoprotein 1; colchicin sensitivity; doxorubicin resistance; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD_antigen: CD243

products gene name :

ABCB1

products gene name syn :

MDR1; P Glycoprotein

other gene names :

ABCB1; ABCB1; CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; MDR1; PGY1

uniprot entry name :

MDR1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Gibbon, Gorilla, Human. Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)

sequence length :

1280

specificity :

Human ABCB1 / MDR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

0.7 mg/ml

storage stability :

Long term: -70 degree C; Short term: +4 degree C

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (20 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic 17 amino acid peptide from cytoplasmic domain of human ABCB1 / MDR1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (94%); Mouse, Hamster (82%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: ABCB1 / MDR1 / P Glycoprotein antibody was raised against synthetic 17 amino acid peptide from cytoplasmic domain of human ABCB1 / MDR1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (94%); Mouse, Hamster (82%). Antigen Modification: Cytoplasmic Domain

products categories :

Family: Transporter. Subfamily: ATP-binding cassette - ABCB/MDR

products description :

ABCB1/MDR1/P Glycoprotein is an ATP dependent transporter that mediates efflux of chemotherapeutic agents from the intracellular milieu. P Glycoprotein has also been associated with volume-regulated chloride channel activity and basal to apical transendothelial migration of mononuclear phagocytes.

ncbi gi num :

42741659

ncbi acc num :

NP_000918.2

ncbi gb acc num :

NM_000927.4

uniprot acc num :

P08183

ncbi mol weight :

134,032 Da

ncbi pathways :

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (106573); Abacavir Transmembrane Transport Pathway (645350); Abacavir Transport And Metabolism Pathway (645349); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Codeine And Morphine Metabolism Pathway (198831); Drug Induction Of Bile Acid Pathway (698755); HIF-1-alpha Transcription Factor Network Pathway (138045)

ncbi summary :

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]

uniprot summary :

ABCB1: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8. Protein type: Membrane protein, integral; Transporter; EC 3.6.3.44; Transporter, ABC family; Hydrolase; Membrane protein, multi-pass; Cell adhesion. Chromosomal Location of Human Ortholog: 7q21.12. Cellular Component: cell surface; membrane; integral to membrane; plasma membrane. Molecular Function: protein binding; ATPase activity, coupled to transmembrane movement of substances; transporter activity; ATP binding; xenobiotic-transporting ATPase activity. Biological Process: response to drug; transport; xenobiotic transport; multidrug transport; G2/M transition of mitotic cell cycle; transmembrane transport. Disease: Colchicine Resistance; Inflammatory Bowel Disease 13

size1 :

0.05 mg

price1 :

495 USD