This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
RABBIT ANTI ATM (aa1980-2338)
catalog :
MBS222387
quantity :
0.1 ml
price :
440 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot
product information
catalog number :
MBS222387
products type :
Antibody
products full name :
RABBIT ANTI ATM (aa1980-2338)
products short name :
ATM
other names :
serine-protein kinase ATM; Serine-protein kinase ATM; serine-protein kinase ATM; A-T mutated; AT mutated; TEL1, telomere maintenance 1, homolog; ataxia telangiectasia mutated; ATM serine/threonine kinase; Ataxia telangiectasia mutated; A-T mutated
products gene name :
ATM
other gene names :
ATM; ATM; AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1; A-T mutated
uniprot entry name :
ATM_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Hamster, Monkey, Mouse
sequence length :
3056
specificity :
This item recognises the human ATM protein, a 350kD polypeptide that is the product of the ATM gene. The ATM gene is defective in Ataxia telangiectasia.ATM protein is expressed within the nucleus of all normal cells and is thought to be important in detection of DNA damage.
form :
Serum. Serum - liquid
storage stability :
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Paraffin*, Western Blot (WB)
app notes :
Immunohistology - Paraffin: Maximum Dilution: 1/50; Application Note: This product requires heat mediated treatment of paraffin sections. MyBioSource recommend the use of antigen unmasking fluid for this purpose. A two hour incubation with this item is recommended. . Western Blotting: Minimum Dilution: 1/500; Maximum Dilution: 1/1000
other info1 :
Perservative Stabilisers: 0.09% Sodium Azide
other info2 :
Immunogen: Recombinant human ATM fragment (amino acids 1980-2338). Antiserum Preparation: Antisera to ATM were raised by repeated immunisation of rabbits with highly purified antigen. Target Species: Human
products description :
MBS222387 recognises the human ATM protein, a 350kD polypeptide that is the product of the ATM gene. The ATM gene is defective in Ataxia telangiectasia. ATM protein is expressed within the nucleus of all normal cells and is thought to be important in detection of DNA damage.
ncbi gi num :
71902540
ncbi acc num :
NP_000042.3
ncbi gb acc num :
NM_000051.3
uniprot acc num :
Q13315
ncbi mol weight :
350,687 Da
ncbi pathways :
ATM Mediated Phosphorylation Of Repair Proteins Pathway 105865!!ATM Mediated Response To DNA Double-strand Break Pathway 105864!!Apoptosis Pathway 83060!!Apoptosis Pathway 470!!Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway 160939!!BARD1 Signaling Events Pathway 137959!!BRCA1-associated Genome Surveillance Complex (BASC) Pathway 413428!!BRCA1-associated Genome Surveillance Complex (BASC) Pathway 890555!!Canonical NF-kappaB Pathway 138030!!Cell Cycle Pathway 530733
ncbi summary :
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
size :
0.1 ml
price :
440 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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