RABBIT ANTI GSK3 BETA (pSer9) | MyBioSource MBS221520 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI GSK3 BETA (pSer9)

catalog :

MBS221520

quantity :

0.1 mL

price :

705 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, chicken, cow, zebrafish

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS221520

products type :

Antibody

products full name :

RABBIT ANTI GSK3 BETA (pSer9)

products short name :

GSK3 BETA

other names :

glycogen synthase kinase-3 beta; Glycogen synthase kinase-3 beta; glycogen synthase kinase-3 beta; FA; GSK-3 beta; factor A; serine/threonine-protein kinase GSK3B; glycogen synthase kinase 3 beta; Factor A; FA; Serine/threonine-protein kinase GSK3B (EC:2.7.11.1)

products gene name :

GSK3 BETA

other gene names :

Gsk3b; Gsk3b; GSK-3 beta; FA

uniprot entry name :

GSK3B_RAT

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Bovine (Expected from Sequence), Chicken (Expected from Sequence), Dog (Expected from Sequence), Human (Expected from Sequence), Mouse (Expected from Sequence), Primate (Expected from Sequence), Xenopus (Expected from Sequence), Zebrafish (Expected from S

sequence length :

420

specificity :

This item recognises glycogen synthase 3 (GSK3) beta phosphorylated at serine 9. This is a 46 kDa member of the serine/threonine protein kinase family. Two isforms of GSK3 exist, alpha and beta. GSK3 beta is expressed in the testis, thymus, prostate, and ovary as well as being expressed at low levels in lung, brain and kidney tissue. GSK3 beta is involved in many signalling pathways including energy metabolism, body pattern formation and microtubule growth and stability (which aids axon growth). GSK3 beta is also thought to be involved in oncogenesis and the hormonal control of several regulatory proteins including glycogen synthase. Phosphorylation of serine-9 inhibits GSK3 beta function.

form :

Purified. Purified IgG - liquid

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch.

tested application :

Western Blot (WB)*

app notes :

Western Blot: This item detects a band of approximately 46kDa in rat cortex cell lysates. Western Blotting: Maximum Dilution: 1/1000; Application Note: Special conditions apply. See *

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3). 50% Glycerol. 0.01% Bovine Serum Albumin

other info2 :

Immunogen: Phosphopeptide corresponding to amino acid sequence surrounding phoshorylated seine 9 of rat GSK3 beta. Buffer Solution: 10mM Hepes pH7.5. Antiserum Preparation: Antisera to rat GSK3 beta (pSer9) were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Rat

products description :

MBS221520 recognises glycogen synthase 3 (GSK3) beta phosphorylated at serine 9. This is a 46 kDa member of the serine/threonine protein kinase family. Two isforms of GSK3 exist, alpha and beta. GSK3 beta is expressed in the testis, thymus, prostate, and ovary as well as being expressed at low levels in lung, brain and kidney tissue. GSK3 beta is involved in many signalling pathways including energy metabolism, body pattern formation and microtubule growth and stability (which aids axon growth). GSK3 beta is also thought to be involved in oncogenesis and the hormonal control of several regulatory proteins including glycogen synthase. Phosphorylation of serine-9 inhibits GSK3 beta function.

ncbi gi num :

14091770

ncbi acc num :

NP_114469.1

ncbi gb acc num :

NM_032080.1

uniprot acc num :

P18266

ncbi mol weight :

46,742 Da

ncbi pathways :

AKT Phosphorylates Targets In The Cytosol Pathway (1120579); AMER1 Mutants Destabilize The Destruction Complex Pathway (1121973); APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway (1121968); APC Truncation Mutants Have Impaired AXIN Binding Pathway (1121969); AXIN Missense Mutants Destabilize The Destruction Complex Pathway (1121972); AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway (1121970); Adaptive Immune System Pathway (1121508); Alzheimer's Disease Pathway (83489); Alzheimer's Disease Pathway (509); Axon Guidance Pathway (83457)

ncbi summary :

mediates Par6-atypical protein kinase C (aPKC) complex regulation of cell polarity; may induce apoptosis [RGD, Feb 2006]

uniprot summary :

GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation. Protein type: Protein kinase, CMGC; EC 2.7.11.1; EC 2.7.11.26; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CMGC group; GSK family; GSK subfamily. Cellular Component: centrosome; protein complex; dendritic spine; cytosol; beta-catenin destruction complex; ribonucleoprotein complex; lipid raft; nucleoplasm; growth cone; membrane; cell soma; perinuclear region of cytoplasm; cytoplasm; plasma membrane; dendritic shaft; nucleus. Molecular Function: p53 binding; beta-catenin binding; protein kinase binding; transcription factor binding; protein kinase activity; integrin binding; ionotropic glutamate receptor binding; protein serine/threonine kinase activity; NF-kappaB binding; protein binding; ubiquitin protein ligase binding; tau-protein kinase activity; kinase activity; tau protein binding; ATP binding. Biological Process: glycogen metabolic process; circadian rhythm; fat cell differentiation; negative regulation of MAP kinase activity; genetic imprinting; re-entry into mitotic cell cycle; positive regulation of protein binding; positive regulation of apoptosis; response to lithium ion; protein amino acid autophosphorylation; positive regulation of axon extension; establishment and/or maintenance of cell polarity; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; positive regulation of protein export from nucleus; protein export from nucleus; negative regulation of protein binding; positive regulation of cell-matrix adhesion; myoblast fusion; ER overload response; response to drug; regulation of microtubule-based process; cell migration; Wnt receptor signaling pathway; hippocampus development; myotube differentiation; negative regulation of dendrite morphogenesis; negative regulation of NFAT protein import into nucleus; positive regulation of peptidyl-serine phosphorylation; peptidyl-serine phosphorylation; negative regulation of neuron maturation; organ morphogenesis; positive regulation of protein complex assembly; axonogenesis; establishment of cell polarity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; phosphorylation; negative regulation of protein complex assembly; negative regulation of apoptosis; regulation of neuronal synaptic plasticity

size1 :

0.1 mL

price1 :

705 USD

more info or order :

MyBioSource product webpage