product summary
request information :
company name :
MyBioSource
product type :
protein
product name :
Interleukin-1 receptor antagonist, Human, Recombinant, E Coli
catalog :
MBS203091
quantity :
0.1 mg
price :
310 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS203091
products type :
Recombinant Protein
products full name :
Interleukin-1 receptor antagonist, Human, Recombinant, E Coli
products short name :
Interleukin-1 receptor antagonist
products name syn :
IL1RN; IL1F3; IL1RA; Interleukin-1 receptor antagonist; IL-1ra; IL-1RN; IRAP; IL1 inhibitor; ICIL-1RA; Anakinra; Interleukin-1 receptor antagonist protein; ICIL 1RA; IL1 inhibitor; ICIL1RA
other names :
interleukin-1 receptor antagonist protein isoform 1; Interleukin-1 receptor antagonist protein; interleukin-1 receptor antagonist protein; IL1 inhibitor; IL1RN (IL1F3); intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); type II interleukin-1 receptor antagonist; interleukin 1 receptor antagonist; ICIL-1RA; IL1 inhibitor; INN: Anakinra
other gene names :
IL1RN; IL1RN; DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA; IL1F3; IL1RA; IL-1RN; IL-1ra; IRAP
uniprot entry name :
IL1RA_HUMAN
sequence length :
177
sequence :
MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
purity :
> 95% by SDS - PAGE
form :
Liquid. In Phosphate buffer saline (pH 7.4)
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human
other info2 :
Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)
products categories :
Hormones & Cytokines
products description :
One of the most potent pro-inflammatory mediators is the early-acting cytokine interleukin-1 (IL-1), whose actions are regulated by the structurally related IL-1 receptor antagonist (IL-1 RA). IL-1 RA is a competitive IL-1 inhibitor and a powerful anti-inflammatory agent. Also, Several autoimmune and inflammatory diseases have been associated with an allelic polymorphism of the IL-1 RA gene. Recombinant human IL-1 RA was expressed in E. coli and purified by using conventional chromatography techniques.
products references :
Capper., et al. (2004) Clin. Exp. Immunol. 138:348 . Roberge CJ., et al. (1994) Journal of Immunology. 152: 5485-94 . Carter DB., et al. (1990) Nature. 344: 633-7 .
ncbi gi num :
27894319
ncbi acc num :
NP_776214
ncbi gb acc num :
NM_173842.2
ncbi mol weight :
17.2kDa (153aa), confirmed by MALDI-TOF.
ncbi pathways :
Cytokine Signaling In Immune System Pathway 366171!!IL-1 Signaling Pathway 198908!!IL1-mediated Signaling Events Pathway 137944!!Immune System Pathway 106386!!Interleukin-1 Signaling Pathway 160141!!Leptin Signaling Pathway 672456!!SIDS Susceptibility Pathways 198901!!Signaling By Interleukins Pathway 160140
ncbi summary :
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
size :
0.1 mg
price :
310 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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