This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
Nicastrin antibody (clone AT3B2)
catalog :
MBS200143
quantity :
0.05 ml
price :
240 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
AT3B2
reactivity :
human, mouse
application :
western blot, ELISA, enzyme immunoassay
product information
catalog number :
MBS200143
products type :
Antibody
products full name :
Nicastrin antibody (clone AT3B2)
products short name :
Nicastrin
products name syn :
nicastrin precursor; nicastrin; KIAA0253; APH2
other names :
nicastrin isoform 1; Nicastrin; nicastrin; anterior pharynx-defective 2; nicastrin
other gene names :
NCSTN; NCSTN; ATAG1874; KIAA0253
uniprot entry name :
NICA_HUMAN
clonality :
Monoclonal
isotype :
IgG2b, k
clone :
AT3B2
host :
Mouse
reactivity :
Human, Mouse
sequence length :
709
purity :
By protein-G affinity chromatography
form :
Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
concentration :
1mg/ml
storage stability :
Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
tested application :
ELISA (EIA), Western Blot (WB) (Tissue)
app notes :
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1000. Recommended starting dilution is 1:500
other info1 :
Antigen Species: Human. Clone: Anti-human Nicastrin mAb, clone AT3B2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Nicastrin protein. Immunogen: Recombinant human Nicastrin (34-153aa) purified from E Coli
products categories :
Immunology
products description :
Nicastrin is a large protein that is a component of an enzyme called gamma-secretase, which is lodged in the cell's membrane. Nicastrin protein is physically associated with presenilin and plays an important role in stabilization and correct localization of presenilin to the membrane-bound gamma-secretase complex. Nicastrin also serves as a docking site for gamma-secretase substrates such as APP and Notch, directly binding to them and presenting them properly to gamma-secretase to ensure the correct cleavage process
products references :
Esler WP, et al., (2002) Proc Natl Acad Sci USA. 99(5):2720-5 Yu G, et al., (2000) Nature.407(6800):48-54
ncbi gi num :
24638433
ncbi acc num :
NP_056146
ncbi gb acc num :
NM_015331.2
ncbi mol weight :
76,744 Da
ncbi pathways :
Activated NOTCH1 Transmits Signal To The Nucleus Pathway 576270!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Axon Guidance Pathway 105688!!Cell Death Signalling Via NRAGE, NRIF And NADE Pathway 106443!!Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway 771595!!Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway 771593!!Degradation Of The Extracellular Matrix Pathway 576263!!Delta-Notch Signaling Pathway 198879
ncbi summary :
This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
size :
0.05 ml
price :
240 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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