catalog number :
MBS175201
products full name :
Anti-PF4 antibody
products short name :
PF4
products name syn :
Platelet factor 4(PF-4); platelet factor 4; C-X-C motif chemokine 4 antibody; Chemokine(C X C motif) ligand 4 antibody; Chemokine(CXC motif) ligand 4 antibody; CXCL 4 antibody; CXCL4 antibody; Iroplact antibody; MGC138298 antibody; Oncostatin A antibody; Oncostatin-A antibody; OncostatinA antibody; PF 4 antibody; PF-4 antibody; PF4 antibody; Platelet factor 4 antibody; PLF4_HUMAN antibody; SCYB 4 antibody; SCYB4 antibody; short form antibody; Small inducible cytokine subfamily member 4 antibody
other names :
Platelet factor 4; Platelet factor 4; platelet factor 4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; platelet factor 4; C-X-C motif chemokine 4; Iroplact; Oncostatin-ACleaved into the following chain:Platelet factor 4, short form
other gene names :
PF4; PF4; PF-4; CXCL4; SCYB4; CXCL4; SCYB4; PF-4
uniprot entry name :
PLF4_HUMAN
purity :
Immunogen affinity purified.
storage stability :
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
tested application :
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
other info1 :
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human PF4 (85-101aa DLQAPLYKKIIKKLLES).
other info2 :
Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
products description :
Description: Rabbit IgG polyclonal antibody for Platelet factor 4(PF4) detection. Tested with WB, IHC-P in Human. Background: CXCL4, Chemokine(C-X-C motif) ligand 4, is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. CXCL4 belongs to the CXC chemokine family. The CXCL4 gene contains 3 exons spanning approximately 1 kb. The gene is encoded on a 10-kb EcoRI fragment of genomic DNA. By in situ hybridization, the CXCL4 gene is mapped to chromosome 4q12-q21. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair.
ncbi mol weight :
10,845 Da
ncbi pathways :
CXCR3-mediated Signaling Events Pathway 138011!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Common Pathway 106060!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Formation Of Fibrin Clot (Clotting Cascade) Pathway 106057
ncbi summary :
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. [provided by RefSeq, Mar 2012]