Anti-ATM antibody | MyBioSource MBS175148 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-ATM antibody

catalog :

MBS175148

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

catalog number :

MBS175148

products type :

Antibody

products full name :

Anti-ATM antibody

products short name :

ATM

products name syn :

Serine-protein kinase ATM; ataxia telangiectasia mutated; A-T mutated antibody; A-T mutated homolog antibody; AT complementation group A antibody; AT complementation group C antibody; AT complementation group D antibody; AT complementation group E antibody; AT mutated antibody; AT protein antibody; AT1 antibody; ATA antibody; Ataxia telangiectasia gene mutated in human beings antibody; Ataxia telangiectasia mutated antibody; Ataxia telangiectasia mutated gene antibody; Ataxia telangiectasia mutated homolog(human) antibody; Ataxia telangiectasia mutated homolog antibody; ATC antibody; ATD antibody; ATDC antibody; ATE antibody; ATM antibody; ATM_HUMAN antibody; DKFZp781A0353 antibody; Human phosphatidylinositol 3 kinase homolog antibody; MGC74674 antibody; OTTHUMP00000232981 antibody; Serine protein kinase ATM antibody; Serine-protein kinase ATM antibody; Serine/threonine-protein kinase ATM antibody; T cell prolymphocytic leukemia antibody; Tefu antibody; TEL1 antibody; TEL1, telomere maintenance 1, homolog antibody; TELO1 antibody; Telomere fusion protein antibody; TPLL antibody

other names :

Serine-protein kinase ATM; Serine-protein kinase ATM; serine-protein kinase ATM; AT mutated; A-T mutated; ataxia telangiectasia mutated; TEL1, telomere maintenance 1, homolog; ATM serine/threonine kinase; Ataxia telangiectasia mutated; A-T mutated

products gene name :

ATM

other gene names :

ATM; ATM; AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1; A-T mutated

uniprot entry name :

ATM_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

3056

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB)

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human ATM (36-50aa DPETIKHLDRHSDSK), different from the related rat and mouse sequences by two amino acids.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Serine-protein kinase ATM(ATM) detection. Tested with WB in Human, Mouse, Rat. Background: ATM(ataxia telangiectasia mutated),also known as TEL1 or TELO1, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. The ATM protein is a member of the phosphatidylinositol 3-kinase family of proteins that respond to DNA damage by phosphorylating key substrates involved in DNA repair and/or cell cycle control. Linkage analysis of ataxia-telangiectasia led to mapping of the ATM gene to chromosome 11q22.3. Using an antiserum developed to a peptide corresponding to the deduced amino acid sequence of ATM, the ATM protein is a single, high molecular weight protein predominantly confined to the nucleus of human fibroblasts, although it is present in both nuclear and microsomal fractions from human lymphoblast cells and peripheral blood lymphocytes. Overexpression of ATM cDNA in AT cells enhanced their survival after radiation exposure, decreased radiation-induced chromosome aberrations, reduced radioresistant DNA synthesis, and partially corrected defective cell cycle checkpoints and induction of stress-activated protein kinase. ATM has an essential role in the reconstitutive capacity of hematopoietic stem cells but is not as important for the proliferation or differentiation of progenitors, in a telomere-independent manner. ATM functions directly in the repair of chromosomal DNA double-stranded breaks by maintaining DNA ends in repair complexes generated during lymphocyte gene assembly.

ncbi gi num :

575773389

ncbi acc num :

Q13315.4

uniprot acc num :

Q13315

ncbi mol weight :

350,687 Da

ncbi pathways :

ATM Mediated Phosphorylation Of Repair Proteins Pathway 105865!!ATM Mediated Response To DNA Double-strand Break Pathway 105864!!Apoptosis Pathway 83060!!Apoptosis Pathway 470!!Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway 160939!!BARD1 Signaling Events Pathway 137959!!BRCA1-associated Genome Surveillance Complex (BASC) Pathway 413428!!BRCA1-associated Genome Surveillance Complex (BASC) Pathway 890555!!Canonical NF-kappaB Pathway 138030!!Cell Cycle Pathway 530733

ncbi summary :

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]

size :

0.1 mg

price :

245 USD