protein

Alpha-2 Macroglobulin (A2M), Rat Serum

MBS173011

0.025 mg

250 USD

Protein

Alpha-2 Macroglobulin (A2M), Rat Serum

Alpha-2-Macroglobulin

Alpha-2 Macroglobulin (A2M), Rat Serum - >=90% (SDS-PAGE)

alpha-2-macroglobulin; Alpha-2-macroglobulin; alpha-2-macroglobulin; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

A2M

A2MAC1; A2m1; A2maa; Mam

A2M; A2M; A2MD; CPAMD5; FWP007; S863-7; CPAMD5; Alpha-2-M

A2MG_HUMAN

1474

>= 90% (SDS-PAGE)

Liquid

At -20 degree C

Source: Rat Serum

Recertification: 2 years. Protein: > 0.5 mg/mL (A280)

Proteins; Antigens; Standards/controls; Native Proteins; Alpha-2 Macroglobulin (a2m)

MyBioSource sells rat serum Alpha-2-Macroglobulin (A2M) for research and diagnostic manufacturing purposes. Custom preparations, technical support, bulk quantities and aliquoting available. Alpha-2-Macroglobulin is a large plasma protein found in the blood that is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. When high resolution images of rat acute-phase alpha 2-macroglobulin were performed, studies showed that the comparison of the amino acid compositions of the protein from rat and human serums indicated a high degree of homology between the two molecules. It was reported that the conformation of rat acute-phase alpha 2-macroglobulin, both at the molecular and secondary structural levels.

119608996

EAW88590.1

~160,000

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); HDL-mediated Lipid Transport Pathway (106158); Hemostasis Pathway (106028); IL6-mediated Signaling Events Pathway (137932); Intrinsic Pathway (106059)

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]

A2M: Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. Protein type: Secreted; Secreted, signal peptide; Inhibitor. Chromosomal Location of Human Ortholog: 12p13.31. Cellular Component: extracellular region; cytosol. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding. Biological Process: negative regulation of complement activation, lectin pathway; extracellular matrix disassembly; platelet activation; regulation of small GTPase mediated signal transduction; extracellular matrix organization and biogenesis; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway. Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency

0.025 mg

250 USD

0.1 mg

480

0.25 mg

710