catalog number :
MBS142245
products type :
Recombinant Protein
products full name :
Recombinant Human Transforming Growth Factor-Beta 3
products short name :
Transforming Growth Factor-Beta 3
products name syn :
TGF b 3 Human; Transforming Growth Factor-Beta 3 Human Recombinant; Transforming Growth Factor-beta3; TGFB3; ARVD; FLJ16571; TGF-beta3
other names :
transforming growth factor beta-3 preproprotein; Transforming growth factor beta-3; transforming growth factor beta-3; TGF-beta-3; prepro-transforming growth factor beta-3; transforming growth factor, beta 3; N/A
products gene name :
TGF b 3
other gene names :
TGFB3; TGFB3; ARVD; RNHF; ARVD1; TGF-beta3; TGF-beta-3; LAP
uniprot entry name :
TGFB3_HUMAN
sequence :
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS.
purity :
Greater than 96.0% as determined by SDS-PAGE.
form :
The protein solution contains 20% Ethanol and 0.12% Acetic acid. Sterile Filtered clear solution.
storage stability :
TGF-beta 3 although stable at room temperature for 3 weeks, should be stored at 4 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
other info2 :
Protein Content: Protein quantitation was carried out by two independent methods:1. UV spectroscopy at 280 nm using the absorbency value of 1.718 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a calibrated solution of TGF-b 3 as a Reference Standard. Biological Activity: The activity is determined by the ability to induce chondrogenic differentiation.
products categories :
CYTOKINES AND GROWTH FACTORS; Growth Factors; Transforming Growth Factor
products description :
Description: TGF-beta 3 Human Recombinant produced in E Coli is a disulfide-linked homodimeric, non-glycosylated, polypeptide chain containing two 112 amino acid chains and having a total molecular mass of 25.5kDa. The TGF-b 3 is purified by standard chromatographic techniques. Introduction: Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGF Betas have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.
ncbi acc num :
NP_003230.1
ncbi gb acc num :
NM_003239.3
ncbi mol weight :
35,708 Da
ncbi pathways :
ALK1 Signaling Events Pathway 137968!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Chronic Myeloid Leukemia Pathway 83116!!Chronic Myeloid Leukemia Pathway 528!!Colorectal Cancer Pathway 83106
ncbi summary :
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]