Mouse monoclonal antibody Anti-Human BIN1 | MyBioSource MBS120424 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human BIN1

catalog :

MBS120424

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2076C2a

reactivity :

human

application :

western blot, dot blot

product information

catalog number :

MBS120424

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human BIN1

products short name :

BIN1

products name syn :

Homo sapiens bridging integrator 1 (BIN1), transcript variant 1, mRNA.; AMPH2; AMPHL; SH3P9; MGC10367; DKFZp547F068

other names :

Homo sapiens bridging integrator 1 (BIN1), transcript variant 1, mRNA; Myc box-dependent-interacting protein 1; myc box-dependent-interacting protein 1; amphiphysin II; amphiphysin-like protein; box dependant MYC interacting protein 1; box-dependent myc-interacting protein 1; bridging integrator 1; Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1

products gene name :

BIN1

other gene names :

BIN1; BIN1; AMPH2; AMPHL; SH3P9

uniprot entry name :

BIN1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

2076C2a

host :

Mouse

reactivity :

Human

sequence length :

2686

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.[NCBI Entrez Gene Summary]

ncbi gi num :

346716175

ncbi acc num :

NP_647593.1

ncbi gb acc num :

NM_139343

ncbi mol weight :

54,948 Da

ncbi pathways :

Arf6 Trafficking Events Pathway (137954)

ncbi summary :

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011]

uniprot summary :

BIN1: May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation. Defects in BIN1 are the cause of centronuclear myopathy type 2 (CNM2). A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. 11 isoforms of the human protein are produced by alternative splicing. Protein type: Cytoskeletal; Tumor suppressor; Adaptor/scaffold; Vesicle. Chromosomal Location of Human Ortholog: 2q14. Cellular Component: I band; synaptic vesicle; membrane; axon; cytoplasm; T-tubule; nerve terminal; nucleus; Z disc; actin cytoskeleton. Molecular Function: identical protein binding; GTPase binding; protein binding; protein heterodimerization activity; protein complex binding; tau protein binding. Biological Process: cell proliferation; muscle cell differentiation; viral reproduction; regulation of neuron differentiation; positive regulation of apoptosis; positive regulation of endocytosis; endocytosis; positive regulation of GTPase activity; positive regulation of astrocyte differentiation. Disease: Myopathy, Centronuclear, 2

size1 :

0.1 mg

price1 :

345 USD