catalog number :
MBS120312
products full name :
Mouse monoclonal antibody Anti-Human VDR
products short name :
VDR
products name syn :
Homo sapiens vitamin D (1,25-dihydroxyvitamin D3) receptor ; NR1I1
other names :
Homo sapiens vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene, complete cds; Vitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1
uniprot entry name :
VDR_HUMAN
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein. [NCBI Entrez Gene Summary]
ncbi mol weight :
53,883 Da