antibody

Mouse monoclonal antibody Anti-Human NCOA3

MBS120285

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

2616C2a

western blot, dot blot

Antibody

Mouse monoclonal antibody Anti-Human NCOA3

NCOA3

Homo sapiens nuclear receptor coactivator 3 (NCOA3), transcript variant 1; ACTR;AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-1; CAGH16;TNRC14; TNRC16; TRAM-1; MGC141848

Homo sapiens nuclear receptor coactivator 3 (NCOA3), transcript variant 1, mRNA; Nuclear receptor coactivator 3; nuclear receptor coactivator 3; CBP-interacting protein; amplified in breast cancer 1 protein; class E basic helix-loop-helix protein 42; receptor-associated coactivator 3; steroid receptor coactivator protein 3; thyroid hormone receptor activator molecule 1; nuclear receptor coactivator 3; ACTR; Amplified in breast cancer 1 protein; AIB-1; CBP-interacting protein; pCIP; Class E basic helix-loop-helix protein 42; bHLHe42; Receptor-associated coactivator 3; RAC-3; Steroid receptor coactivator protein 3; SRC-3; Thyroid hormone receptor activator molecule 1; TRAM-1

NCOA3

NCOA3; NCOA3; ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42

NCOA3_HUMAN

Monoclonal

IgG1

2616C2a

Mouse

Human

7996

100 ug/ml (1.0 ml)

Dot Blot (DB)

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [NCBI Entrez Gene Summary]

291490680

NP_858045.1

NM_181659

154,892 Da

Androgen Receptor Signaling Pathway (198806); Developmental Biology Pathway (477129); FOXA1 Transcription Factor Network Pathway (137979); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Integrated Breast Cancer Pathway (219801); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPARA Activates Gene Expression Pathway (530749); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (119544); Retinoic Acid Receptors-mediated Signaling Pathway (138039)

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

SRC-3: a histone acetyltransferase and nuclear receptor coactivator. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Activity is enhanced by various hormones and TNF. Acetylation by CREBBP may suppress coactivation of target genes by disrupting its association with nuclear receptors. Frequently amplified or overexpressed in breast and ovarian cancers. Five alternatively spliced isoforms have been described. Protein type: Transcription, coactivator/corepressor; EC 2.3.1.48; Acetyltransferase; Motility/polarity/chemotaxis; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 20q12. Cellular Component: nucleoplasm; cytoplasm; nucleus. Molecular Function: protein dimerization activity; ligand-dependent nuclear receptor binding; protein binding; signal transducer activity; histone acetyltransferase activity; ligand-dependent nuclear receptor transcription coactivator activity; androgen receptor binding; transcription coactivator activity; protein N-terminus binding; chromatin binding; thyroid hormone receptor binding; nuclear hormone receptor binding. Biological Process: developmental growth; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; multicellular organism growth; androgen receptor signaling pathway; vagina development; positive regulation of transcription from RNA polymerase II promoter; histone acetylation; positive regulation of keratinocyte differentiation; cellular response to hormone stimulus

0.1 mg

345 USD