This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
Mouse monoclonal antibody Anti-Human BRIP1
catalog :
MBS120152
quantity :
0.1 mg
price :
345 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2091C2a
reactivity :
human
application :
western blot, dot blot
product information
catalog number :
MBS120152
products type :
Antibody
products full name :
Mouse monoclonal antibody Anti-Human BRIP1
products short name :
BRIP1
products name syn :
Homo sapiens BRCA1 interacting protein C-terminal helicase 1 (BRIP1); OF; BACH1; FANCJ; FLJ90232; MGC126521;MGC126523
other names :
Homo sapiens BRCA1 interacting protein C-terminal helicase 1 (BRIP1), mRNA; Fanconi anemia group J protein; Fanconi anemia group J protein; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1/BRCA2-associated helicase 1; BRCA1 interacting protein C-terminal helicase 1; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1-interacting protein 1
products gene name :
BRIP1
other gene names :
BRIP1; BRIP1; OF; BACH1; FANCJ
uniprot entry name :
FANCJ_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
2091C2a
host :
Mouse
reactivity :
Human
sequence length :
8166
concentration :
100 ug/ml (1.0 ml)
tested application :
Dot Blot (DB)
other info1 :
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
other info2 :
Sterility: Filtered through a 0.22 um membrane.
products description :
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [NCBI Entrez Gene Summary]
ncbi gi num :
301897117
ncbi acc num :
NP_114432.2
ncbi gb acc num :
NM_032043
ncbi mol weight :
112,476 Da
ncbi pathways :
Cytosolic Iron-sulfur Cluster Assembly Pathway (771576); DNA Repair Pathway (105837); Double-Strand Break Repair Pathway (105861); Fanconi Anemia Pathway (377262); Fanconi Anemia Pathway (377128); Homologous DNA Pairing And Strand Exchange Pathway (105870); Homologous Recombination Repair Pathway (105862); Homologous Recombination Repair Of Replication-independent Double-strand Breaks Pathway (105863); Metabolism Pathway (477135)
ncbi summary :
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]
uniprot summary :
BRIP1: a DNA-dependent ATPase and DNA helicase required for the maintenance of chromosomal stability. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Binds directly to the BRCT domains of BRCA1. Defects in BRIP1 cause of susceptibility to breast cancer and Fanconi anemia. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Belongs to the DEAD box helicase family, DEAH subfamily. Two alternatively spliced human isoforms have been described. Protein type: Oncoprotein; Helicase; EC 3.6.4.13. Chromosomal Location of Human Ortholog: 17q22.2. Cellular Component: nuclear membrane; cytoplasm; nucleus. Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; 4 iron, 4 sulfur cluster binding; metal ion binding; ATP binding. Biological Process: regulation of transcription from RNA polymerase II promoter; double-strand break repair; DNA damage checkpoint; DNA duplex unwinding. Disease: Fanconi Anemia, Complementation Group J; Breast Cancer; Tracheoesophageal Fistula With Or Without Esophageal Atresia
size1 :
0.1 mg
price1 :
345 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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