This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
CYP46A1 / CYP46 Antibody (C-Terminus, Serum) LS-C56817
catalog :
LS-C56817
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA
product information
AntibodyID :
57287
AntibodyName :
LS-C56817
TargetSpecies :
Human
Host Species :
Goat
Product Name :
CYP46A1 / CYP46 Antibody (C-Terminus, Serum) LS-C56817
Specificity :
Recognizes cholesterol 24-hydroxylase (CYP46A1), a 58 kD member of the Cytochrome P450 family, expressed in the brain. CYP46A1 converts cholesterol into the biologically active oxysterol and 24(S)-hydroxycholesterol, in the first step of the enzymatic degradation of cholesterol in the brain. CYP46A1 is also thought to play a role in the metabolism of neurosteroids and drugs that can cross the blood-brain barrier and are targeted to the central nervous system. P450 enzymes are divided into two groups: steroidogenic and xenobiotic. The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism. Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members: CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1.
ClonalityDesc :
Polyclonal
AntibodyModification :
Serum Unconjugated
AntigenModification :
C-Terminus
PresentationDesc :
0.09% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide corresponding to amino acid sequence 254-270 of human cholesterol 24-hydroxylase protein.
PurificationDesc :
Antiserum
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
CYP46A1 / CYP46
StandardGeneSymbol :
CYP46A1
gene family :
Cytochrome P450
Reactivity :
Human
Usage :
ELISA (1:15000), WB (1:3000)
ShortWebDescription :
CYP46 antibody LS-C56817 is an unconjugated goat polyclonal antibody to human CYP46 (CYP46A1 ). Validated for ELISA and WB.
UsageText :
Western Blot: LS-C56817 detects a band of approximately 58kD in human Alzheimer diseased brain lysates.
Synonyms :
CYP46A1, Cytochrome P450 46A1, Cholesterol 24-hydroxylase, CH24H, CP46, CYP46
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.