LifeSpan Biosciences

antibody

Anti-BMP4 / BMP-4

LS-C44861

monoclonal

mouse

human

western blot, ELISA

44599

LS-C44861

Human

Mouse

Anti-BMP4 / BMP-4

Recognizes the disulphide-linked homodimeric cysteine knot protein known as human Bone Morphogenetic Protein 4 (BMP-4/BMP-2b), full-length 408aa. BMP-4 is a member of the Transforming Growth Factor beta (TGF-B) superfamily and one of a growing number of osteogenic proteins shown to induce bone and cartilage formation and to play an important role in developmental processes, including cell proliferation, differentiation, apoptosis and morphogenesis. BMPs act through binding with a receptor complex consisting of type I and type II serine/threonine kinases, resulting ultimately in the activation of the Smad protein and mitogen-activated protein kinase (MAPK) signaling pathways. Several antagonist proteins, including, noggin, chordin, gremlin and follistatin, are responsible for modulating the signaling effects of BMPs, through the binding and blocking of receptor ligands, thereby preventing activation. Research studies have verified the particular importance of BMP-4 in epithelial-mesenchymal interactions, including its vital role in the early stages of tooth morphogenesis (3), the interaction between BMP-4 and its antagonist noggin in hair follicles (4) and the effects of BMP-4 expression/signaling in organs, including the lungs (5) and eyes (6)

Monoclonal

3H2

PBS, pH 7.2, 0.09% sodium azide.

Recombinant Human BMP-4 expressed in E. coli.

Protein G purified

+4°C or -20°C, Avoid repeated freezing and thawing.

IgG2b

BMP4 / BMP-4

BMP4

TGF beta

Human

ELISA (1 - 4 µg/ml), WB (0.25 µg/ml)

Western Blot: LS-C44861 detects a band of approximately 44kD due to glycosylation.

BMP4, BMP-2B, BMP-4, BMP2B, BMP2B1, Bone morphogenetic protein 2B, Bone morphogenetic protein 4, DVR4, MCOPS6, OFC11, Zyme