This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
Anti-YWHAG / 14-3-3 Gamma Antibody (N-Terminus) LS-C42373
catalog :
LS-C42373
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry - paraffin section
product information
AntibodyID :
42111
AntibodyName :
LS-C42373
TargetSpecies :
Sheep
Host Species :
Rabbit
Product Name :
Anti-YWHAG / 14-3-3 Gamma Antibody (N-Terminus) LS-C42373
Specificity :
Recognizes the acetylated N-terminal of 14-3-3gamma, a member of the 14-3-3 family which consists of 30 kD proteins involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for it's different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3gamma is thought to play an important role in muscle, being induced by growth factors in human vascular smooth muscle cells, and being expressed in skeletal and heart muscles. An example is the gamma isoform binds muscle-specific receptor tyrosine kinase regulating synaptic gene transmission. The gamma isoform binds amyloid beta-protein precursor intracellular domain fragment (AICD) and FE65, facilitating FE65-dependent gene transactivation. The binding of 14-3-3gamma to glial fibrillary acidic protein is important in the regulation of glial filaments. 14-3-3 gamma binds and may regulate CDK11 during the cell cycle and apoptosis. The gamma isoform is lowered in fetal Downs syndrome brains.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
N-Terminus
PresentationDesc :
Serum, 0.09% sodium azide.
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide corresponding to acetylated N-terminal of sheep 14-3-3 gamma.
IsotypeName :
IgG
Gene :
YWHAG / 14-3-3 Gamma
StandardGeneSymbol :
YWHAG
Reactivity :
Chicken, Sheep, Bovine, Mouse, Rat, Human
Usage :
ELISA, IHC-P (1:800), WB (1:6000 - 1:12000)
UsageText :
Western Blot: LS-C42373 detects a band of approximately 30kD in HEK293 cell lysates. Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Synonyms :
YWHAG, 14-3-3GAMMA, 14-3-3 gamma, 14-3-3 protein gamma, KCIP-1
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.