This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
YWHAB / 14-3-3 Beta Antibody (N-Terminus, Serum) LS-C42370
catalog :
LS-C42370
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry - paraffin section
product information
AntibodyID :
42108
AntibodyName :
LS-C42370
TargetSpecies :
Sheep
Host Species :
Rabbit
Product Name :
YWHAB / 14-3-3 Beta Antibody (N-Terminus, Serum) LS-C42370
Specificity :
Recognizes the acetylated N-terminal of 14-3-3 beta. It is a member of the 14-3-3 family which consists of 30 kD proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for it's different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 beta plays a role in the pathogenesis of systemic lupus erythematosus and is involved in negative regulation of p90 ribosomal S6 kinase activity and tuberous sclerosis tumor suppressor proteins. It also binds IGF-1 receptor, RAF1 and CDC25 phosphatases. May not react with recombinant proteins that are not N-acetylated.
ClonalityDesc :
Polyclonal
AntibodyModification :
Serum Unconjugated
AntigenModification :
N-Terminus
PresentationDesc :
0.09% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide corresponding to acetylated N-Terminus sequence of sheep 14-3-3 beta.
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
IsotypeName :
IgG
Gene :
YWHAB / 14-3-3 Beta
StandardGeneSymbol :
YWHAB
Reactivity :
Sheep
NonReactiveSpecies :
Amphibia, Fish, Fungus, Invertebrates, Reptile, Yeast
Usage :
ELISA, IHC-P (1:600), WB (1:3000)
ShortWebDescription :
14-3-3 Beta antibody LS-C42370 is an unconjugated rabbit polyclonal antibody to sheep 14-3-3 Beta (YWHAB ). Validated for ELISA, IHC and WB.
UsageText :
Western Blot: LS-C42370 detects a band of approximately 30kD in HEK293 cell lysates. Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Synonyms :
YWHAB, 14-3-3 alpha, 14-3-3 Beta, 14-3-3 protein beta/alpha, GW128, Protein 1054, HS1, KCIP-1, YWHAA
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.