This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
PSEN2 / Presenilin 2 Antibody (aa31-47) LS-C11498
catalog :
LS-C11498
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human
application :
immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
product information
AntibodyID :
12239
AntibodyName :
LS-C11498
TargetSpecies :
Human
Host Species :
Goat
Product Name :
PSEN2 / Presenilin 2 Antibody (aa31-47) LS-C11498
Specificity :
Recognizes human presenilin-2 (PSEN2), binding to neurons in both normal and Alzheimer's disease brain. Mutation of PSEN2 is associated with the early onset form of autosomal dominant Alzheimer's disease. PSEN2 is an essential component of the gamma-secretase complex along with APH-1 (APH-1A or APH-1B), PSEN1, Pen-2 (PEN2), and nicastrin (NCSTN). This endoprotease complex plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
aa31-47
PresentationDesc :
Serum, 0.09% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide corresponding to amino acids 31-47 of Presenilin-2.
PurificationDesc :
Antiserum
IsotypeName :
IgG
Gene :
PSEN2 / Presenilin 2
StandardGeneSymbol :
PSEN2
gene family :
Protease
Subfamily :
Aspartic A22A
Reactivity :
Human
Usage :
ELISA (1:20000), IHC, IHC-Fr (1:1000), IHC-P (1:300)
ShortWebDescription :
Presenilin 2 antibody LS-C11498 is an unconjugated goat polyclonal antibody to human Presenilin 2 (PSEN2 ). Validated for ELISA and IHC.
UsageText :
Immunohistology: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
Synonyms :
PSEN2, AD3LP, AD4, AD5, AD3L, CMD1V, PS-2, PSNL2, PS2, STM2, Presenilin 2, STM-2, E5-1, Presenilin-2
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.