This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon
product type :
antibody
product name :
PDH subunit E2 / E3bp Antibody (13G2AE2BH5)
catalog :
A-21326
quantity :
100µg
price :
US 339.00
clonality :
monoclonal
host :
mouse
reactivity :
human, mouse, rat, cow
application :
western blot, immunocytochemistry
product information
Product Type :
Antibody
Product Name :
PDH subunit E2 / E3bp Antibody (13G2AE2BH5)
Catalog # :
A-21326
Quantity :
100µg
Price :
US 339.00
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Bv, Hu, Ms, Rt
Applications :
Western Blot: 1.0 ug/ml, Immunofluorescence: Assay Dependent
Species :
Bv, Hu, Ms, Rt
Clone :
13G2AE2BH5
Isotype :
IgG2a, kappa
Storage :
4¡ C
Description :
DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure.
Immunogen :
Porcine PDH.
Format :
Liquid
Applications w/Dilutions :
WB 1.0 ug/ml, IF Assay Dependent
Aliases :
DLTA, PDC-E2, PDCE2, 70 kDa mitochondrial autoantigen of primary biliary cirrhosis, E2 component of pyruvate dehydrogenase complex, M2 antigen complex 70 kDa subunit, PBC, dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, dihydrolipoyllysine-residue a
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
www.thermofisher.com
800-678-5599
headquarters: USA