Phospho-ERK1/ERK2 (Thr185, Tyr187) Polyclonal Antibody, Alexa Fluor 488

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-ERK1/ERK2 (Thr185, Tyr187) Polyclonal Antibody, Alexa Fluor 488

catalog :

44-680A1

quantity :

100µL

price :

US 309.00

clonality :

polyclonal

host :

rabbit

conjugate :

AF488

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

immunocytochemistry

more info or order :

Invitrogen product webpage

product information

Product Type :

Antibody

Product Name :

Phospho-ERK1/ERK2 (Thr185, Tyr187) Polyclonal Antibody, Alexa Fluor 488

Catalog # :

44-680A1

Quantity :

100µL

Price :

US 309.00

Clonality :

Polyclonal

Purity :

purified

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay Dependent

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20°C

Description :

ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well. Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase (ERK) 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1.

Immunogen :

Synthetic phosphopeptide derived from the region of ERK1 that contains threonine 202 (corresponding to 185 in ERK2) and tyrosine 204 (corresponding to 187 in ERK2)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay Dependent

Aliases :

Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2 , MAPK1, ERK2, PRKM1, PRKM2, Mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1, MAPK3, ERK1, PRKM3, p44, p42

more info or order :

Invitrogen product webpage