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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Phospho-MEK1/MEK2 (Ser218, Ser222, Ser226) Polyclonal Antibody
catalog :
44-454G
quantity :
10 blots
price :
US 309.00
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry
more info or order :
Invitrogen product webpage
citations: 1
Reference
Rehani K, Wang H, Garcia C, Kinane D, Martin M. Toll-like receptor-mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2. J Immunol. 2009;182:547-53 pubmed
product information
Product Type :
Antibody
Product Name :
Phospho-MEK1/MEK2 (Ser218, Ser222, Ser226) Polyclonal Antibody
Catalog # :
44-454G
Quantity :
10 blots
Price :
US 309.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Immunocytochemistry: 5 µg/ml, Immunofluorescence: 5 µg/ml, Western Blot: 1:500-1:2000
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
-20°C
Description :
MAP2K1 is a dual specificity mitogen-activated protein kinase (MAPK) kinase. It is an essential component of the MAP kinase pathway and stimulates the enzymatic activity of MAP kinases in response to various signals. Growth factors, cytokines, and proto-oncogenes transduce their signals through the activation of RAS, which leads to activation of the serine/threonine kinase RAF, and then to activation of MAPK kinase. MAP2K1 is activated by the Raf family member p74raf-1, through phosphorylation of serine residues at positions 217 and 221 in the activation loop.
Immunogen :
Synthetic phosphopeptide derived from a region of human MEK1 that contains serine 218 and serine 222
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 5 µg/ml, Immunofluorescence: 5 µg/ml, Western Blot: 1:500-1:2000
Aliases :
Dual specificity mitogen-activated protein kinase kinase 1, EC 2.7.12.2, ERK activator kinase 1, MAP kinase kinase 1, MAP2K1, MAPK/ERK kinase 1, MAPKK 1, MAPKK1, MEK1, MP2K1, PRKMK1, kinase MEK1
PubMed References :
19109187
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
www.thermofisher.com
800-678-5599
headquarters: USA