beta Amyloid (1-40) Polyclonal Antibody, Biotin | Invitrogen 44-3489 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

beta Amyloid (1-40) Polyclonal Antibody, Biotin

catalog :

44-3489

quantity :

25µg

price :

US 399.00

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human

application :

dot blot

more info or order :

Invitrogen product webpage

citations: 3

Reference
Sagare A, Bell R, Srivastava A, Sengillo J, Singh I, Nishida Y, et al. A lipoprotein receptor cluster IV mutant preferentially binds amyloid-? and regulates its clearance from the mouse brain. J Biol Chem. 2013;288:15154-66 pubmed publisher
Wegiel J, Kuchna I, Nowicki K, Frackowiak J, Mazur Kolecka B, Imaki H, et al. Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration. Acta Neuropathol. 2007;113:389-402 pubmed
Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, et al. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci. 2005;25:11495-503 pubmed

product information

Product Type :

Antibody

Product Name :

beta Amyloid (1-40) Polyclonal Antibody, Biotin

Catalog # :

44-3489

Quantity :

25µg

Price :

US 399.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Dot blot: 0.05-1.0 µg/mL, Functional Assay: Assay Dependent, Radioimmune Assays: Assay Dependent

Species :

Human

Isotype :

IgG

Storage :

-80°C

Description :

Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease. Abeta peptide is 40-43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease, beta-secretase (BACE) which is synthesized as a propeptide and must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP, and a membrane-bound remnant. The remnant protein is processed by another protease, gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. The transmembrane glycoprotein, nicastrin, is associated with presinilins and has been found to bind to the carboxyl-terminus of beta APP and helps to modulate the production of the amyloid beta peptide. Abeta is an extracellular filamentous protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles. Alzheimer’s disease, the most common cause of senile dementia, is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type), cerebroarterial amyloidosis (cerebral amyloid angiopathy) and in the Guam Parkinson-Dementia complex.

Immunogen :

1-40 of Amyloid Beta

Format :

Liquid

Applications w/Dilutions :

Dot blot: 0.05-1.0 µg/mL, Functional Assay: Assay Dependent, Radioimmune Assays: Assay Dependent

Aliases :

AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2, Alzheimer disease amyloid A4 protein homolog, APP, Amyloidogenic glycoprotein AG, Amyloid beta A4 protein, amyloid beta (A4) precursor protein, Peptidase nexin-II

more info or order :

Invitrogen product webpage