beta Amyloid (1-42) Polyclonal Antibody, Biotin | Invitrogen 44-3449 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

beta Amyloid (1-42) Polyclonal Antibody, Biotin

catalog :

44-3449

quantity :

25µg

price :

US 399.00

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human

application :

dot blot

more info or order :

Invitrogen product webpage

citations: 2

Reference
Guo D, Zhou T, Arainga M, Palandri D, Gautam N, BRONICH T, et al. Creation of a Long-Acting Nanoformulated 2',3'-Dideoxy-3'-Thiacytidine. J Acquir Immune Defic Syndr. 2017;74:e75-e83 pubmed publisher
Malachias M, Paulo César Veiga Jardim P, Almeida F, Lima E, Feitosa G. 7th Brazilian Guideline of Arterial Hypertension: Chapter 7 - Pharmacological Treatment. Arq Bras Cardiol. 2016;107:35-43 pubmed publisher

product information

Product Type :

Antibody

Product Name :

beta Amyloid (1-42) Polyclonal Antibody, Biotin

Catalog # :

44-3449

Quantity :

25µg

Price :

US 399.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Dot blot: 0.05-1.0 ug/ml, Functional Assay: Assay Dependent, Radioimmune Assays: Assay Dependent

Species :

Human

Isotype :

IgG

Storage :

-80°C

Description :

Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE). This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. Found associated with the presenilins is the transmembrane glycoprotein nicastrin. Nicastrin has been found to bind to the carboxyl-terminus of betaAPP and helps to modulate the production of the amyloid beta peptide.

Immunogen :

1-42 of Amyloid Beta

Format :

Liquid

Applications w/Dilutions :

Dot blot: 0.05-1.0 ug/ml, Functional Assay: Assay Dependent, Radioimmune Assays: Assay Dependent

Aliases :

AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2, Alzheimer disease amyloid A4 protein homolog, APP, Amyloidogenic glycoprotein AG, Amyloid beta A4 protein, amyloid beta (A4) precursor protein, Peptidase nexin-II

more info or order :

Invitrogen product webpage