MLH1 Monoclonal Antibody (ZM001) | Invitrogen 39-3200 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MLH1 Monoclonal Antibody (ZM001)

catalog :

39-3200

quantity :

100µg

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ZM001

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:150; tbl 2	Huvila J, Talve L, Carpen O, Edqvist P, Ponten F, Grenman S, et al. Progesterone receptor negativity is an independent risk factor for relapse in patients with early stage endometrioid endometrial adenocarcinoma. Gynecol Oncol. 2013;130:463-9 pubmed publisher
	Al-Temaimi R, Jacob S, Al-Ali W, Thomas D, Al-Mulla F. Reduced FHIT expression is associated with mismatch repair deficient and high CpG island methylator phenotype colorectal cancer. J Histochem Cytochem. 2013;61:627-38 pubmed publisher
	Gomes A, Reis-Silva M, Alarcão A, Couceiro P, Sousa V, Carvalho L. Promoter hypermethylation of DNA repair genes MLH1 and MSH2 in adenocarcinomas and squamous cell carcinomas of the lung. Rev Port Pneumol. 2014;20:20-30 pubmed publisher

product information

Product Type :

Antibody

Product Name :

MLH1 Monoclonal Antibody (ZM001)

Catalog # :

39-3200

Quantity :

100µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay Dependent, Immunohistochemistry: Assay Dependent, Western Blot: Assay Dependent

Species :

Human

Clone :

ZM001

Isotype :

IgG2a, kappa

Storage :

-20°C

Description :

MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPCC). MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.

Immunogen :

Recombinant protein derived from the C-terminal region of the human MLH1 protein

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay Dependent, Immunohistochemistry: Assay Dependent, Western Blot: Assay Dependent

Aliases :

COCA2, FCC2, HNPCC, HNPCC2, hMLH1, DNA mismatch repair protein Mlh1

PubMed References :

23777659, 23797051, 24360395

more info or order :

Invitrogen product webpage