SMAD1 Polyclonal Antibody | Invitrogen 38-5400 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SMAD1 Polyclonal Antibody

catalog :

38-5400

quantity :

100µg

price :

US 309.00

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:50; loading ...; fig 6c	Morgan E, Pittman J, DeGiacomo A, Cusher D, de Bakker C, Mroszczyk K, et al. BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing. J Orthop Res. 2016;34:2096-2105 pubmed publisher
western blot; human; 1:1000; fig 7c	Cyr Depauw C, Northey J, TabariÃ¨s S, Annis M, Dong Z, Cory S, et al. Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion. Mol Cell Biol. 2016;36:1509-25 pubmed publisher
immunocytochemistry; mouse; fig 6	Lee S, Jeong J, Oh C, Park S, Kim J, Kim H, et al. Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation. Sci Rep. 2015;5:16577 pubmed publisher
immunohistochemistry - paraffin section; human	Fontebasso A, Papillon Cavanagh S, Schwartzentruber J, Nikbakht H, Gerges N, Fiset P, et al. Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma. Nat Genet. 2014;46:462-6 pubmed publisher
western blot; human	Chu I, Lai W, Aprelikova O, El Touny L, Kouros Mehr H, Green J. Expression of GATA3 in MDA-MB-231 triple-negative breast cancer cells induces a growth inhibitory response to TGFß. PLoS ONE. 2013;8:e61125 pubmed publisher
western blot; human; fig 1	Grönroos E, Kingston I, Ramachandran A, Randall R, Vizan P, Hill C. Transforming growth factor ? inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes. Mol Cell Biol. 2012;32:2904-16 pubmed publisher
western blot; mouse; fig 5	Vanhara P, Lincová E, Kozubik A, Jurdic P, Soucek K, Smarda J. Growth/differentiation factor-15 inhibits differentiation into osteoclasts--a novel factor involved in control of osteoclast differentiation. Differentiation. 2009;78:213-22 pubmed publisher
	Ma P, Ren B, Yang X, Sun B, Liu X, Kong Q, et al. ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus. Open Biol. 2017;7: pubmed publisher
	Wu M, Ramel M, Howell M, Hill C. SNW1 is a critical regulator of spatial BMP activity, neural plate border formation, and neural crest specification in vertebrate embryos. PLoS Biol. 2011;9:e1000593 pubmed publisher
	Krause C, Korchynskyi O, de Rooij K, Weidauer S, de Gorter D, van Bezooijen R, et al. Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways. J Biol Chem. 2010;285:41614-26 pubmed publisher
	Sehgal R, Sheibani N, Rhodes S, Belecky Adams T. BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression. Dev Biol. 2009;332:429-43 pubmed publisher

product information

Product Type :

Antibody

Product Name :

SMAD1 Polyclonal Antibody

Catalog # :

38-5400

Quantity :

100µg

Price :

US 309.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Non-human primate

Applications :

Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: Assay Dependent

Species :

Human, Mouse, Non-human primate

Isotype :

IgG

Storage :

-20°C

Description :

SMAD1 belongs to the SMAD family of proteins, which are downstream effectors of the TGF beta/BMP signaling pathway. Members of the SMAD family transmit TGF- beta signals from the cell surface into the nucleus. Once in the nucleus, SMADs can target a variety of DNA binding proteins to regulate transcriptional responses. SMAD1 is a receptor-regulated SMAD in the cell to regulate a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation, and apoptosis.

Immunogen :

Synthetic peptide derived from an internal region of the human Smad1 protein.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: Assay Dependent

Aliases :

BSP-1, BSP1, Dwarfin-A, Dwf-A, JV4-1, MADH1, MADR1, Mad-related protein 1, Mad1, Mothers against DPP homolog 1, Mothers against decapentaplegic homolog 1, Mothers-against-DPP-related-1, SMAD 1, Smad 1, Transforming growth factor- beta signaling protein-1

more info or order :

Invitrogen product webpage