NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

antibody

FGFR1 Monoclonal Antibody (M2F12)

37-9200

100µg

US 309.00

monoclonal

mouse

nonconjugated

M2F12

human, rat

western blot, ELISA, immunohistochemistry, immunoprecipitation

FGFR1 Monoclonal Antibody (M2F12)

37-9200

100µg

US 309.00

Monoclonal

protein A

Mouse

Human, Rat

ELISA: Assay Dependent, Immunohistochemistry: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Human, Rat

M2F12

IgG2a, kappa

-20°C

FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family containing an Ig-like domain and a tyrosine kinase domain. FGFR1 has multiple isoforms and is a Type I membrane protein. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR1 binds both acidic and basic fibroblast growth factors and is involved in limb induction. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM. Four genes encoding for high affinity cell surface FGF receptors (FGFRs) have been identified: FGFR-1, FGFR-2, FGFR-3 and FGFR-4. FGFRs are members of the tyrosine kinase family of growth factor receptors. At the mRNA level, FGFR1 is highly expressed in developing human tissues including the brain, vascular basement membrane and skin. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

Recombinant human FGF-R1-alpha (fibroblast growth factor receptor 1, alpha isoform) ectodomain

Liquid

ELISA: Assay Dependent, Immunohistochemistry: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Fibroblast Growth Factor Receptor 1, Basic fibroblast growth factor receptor 1, FGFR-1, bFGF-R, Fms-like tyrosine kinase-2, c-fgr, CD331