PLK1 Monoclonal Antibody (36-298) | Invitrogen 37-7100 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PLK1 Monoclonal Antibody (36-298)

catalog :

37-7100

quantity :

100µg

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

36-298

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig 1	Wu J, Ivanov A, Fisher P, Fu Z. Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling. elife. 2016;5: pubmed publisher
immunohistochemistry; human	Dibb M, Han N, Choudhury J, Hayes S, Valentine H, West C, et al. FOXM1 and polo-like kinase 1 are co-ordinately overexpressed in patients with gastric adenocarcinomas. BMC Res Notes. 2015;8:676 pubmed publisher
western blot; human; 1:200; fig 4	Ito T, Sato F, Kan T, Cheng Y, David S, Agarwal R, et al. Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer. Int J Cancer. 2011;129:2134-46 pubmed publisher
	Duan H, Wang C, Wang M, Gao X, Yan M, Akram S, et al. Phosphorylation of PP1 Regulator Sds22 by PLK1 Ensures Accurate Chromosome Segregation. J Biol Chem. 2016;291:21123-21136 pubmed
	Dai G, Qian Y, Chen J, Meng F, Pan F, Shen W, et al. Calmodulin activation of polo-like kinase 1 is required during mitotic entry. Biochem Cell Biol. 2013;91:287-94 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PLK1 Monoclonal Antibody (36-298)

Catalog # :

37-7100

Quantity :

100µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: Assay Dependent, Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay Dependent, Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Species :

Human, Mouse, Rat

Clone :

36-298

Isotype :

IgG1

Storage :

-20°C

Description :

Considerable evidence indicates that a Polo-Like Kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.

Immunogen :

Full-length human Plk1

Format :

Liquid

Applications w/Dilutions :

Aliases :

Serine/threonine-protein kinase PLK1, Polo-like kinase 1, PLK-1, Serine/threonine-protein kinase 13, STPK13, PLK1, PLK

more info or order :

Invitrogen product webpage