Aurora B Polyclonal Antibody | Invitrogen 36-5200 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Aurora B Polyclonal Antibody

catalog :

36-5200

quantity :

100µg

price :

US 309.00

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig s2	Wu J, Chen C, Coumar M, Lin W, Chen Z, Hsu J, et al. Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules. Proc Natl Acad Sci U S A. 2013;110:E1779-87 pubmed publisher
	Esposito F, Libertini S, Franco R, Abagnale A, Marra L, Portella G, et al. Aurora B expression in post-puberal testicular germ cell tumours. J Cell Physiol. 2009;221:435-9 pubmed publisher
	Zeng W, Navaratne K, Prayson R, Weil R. Aurora B expression correlates with aggressive behaviour in glioblastoma multiforme. J Clin Pathol. 2007;60:218-21 pubmed

product information

Product Type :

Antibody

Product Name :

Aurora B Polyclonal Antibody

Catalog # :

36-5200

Quantity :

100µg

Price :

US 309.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 1 µg/mL, Immunofluorescence: 1 µg/mL, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Species :

Human

Isotype :

IgG

Storage :

-20°C

Description :

Aurora-B kinase (AurB) is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and AurB. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3. AurB is overexpressed in a number of tumours, including primary breast and colon tumour samples. Its expression in tumours seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.

Immunogen :

Synthetic peptide derived from the N-terminal region of the human Aurora B protein.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1 µg/mL, Immunofluorescence: 1 µg/mL, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Aliases :

AIK2, AIM-1, AIM1, ARK2, AURKB, Aurora- and Ipl1-like midbody-associated protein 1, Aurora-B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, EC 2.7.11.1, STK-1, STK12, Serine/threonine protein kinase 12

more info or order :

Invitrogen product webpage