Vinculin Monoclonal Antibody (VLN01) | Invitrogen MA5-11690 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Vinculin Monoclonal Antibody (VLN01)

catalog :

MA5-11690

quantity :

500 µL

price :

US 496.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

VLN01

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 26

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; mouse; loading ...; fig 3a immunoprecipitation; human; loading ...; fig 3c	Cheng J, Kyle J, Lang D, Wiedmeyer B, Guo J, Yin K, et al. An East Asian Common Variant Vinculin P.Asp841His Was Associated With Sudden Unexplained Nocturnal Death Syndrome in the Chinese Han Population. J Am Heart Assoc. 2017;6: pubmed publisher
immunoprecipitation; mouse; loading ...; fig 4a	Cheng J, Kyle J, Wiedmeyer B, Lang D, Vaidyanathan R, Makielski J. Vinculin variant M94I identified in sudden unexplained nocturnal death syndrome decreases cardiac sodium current. Sci Rep. 2017;7:42953 pubmed publisher
western blot; human; fig 4	Currier M, Lee S, Stobart C, Hotard A, Villenave R, Meng J, et al. EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression. PLoS Pathog. 2016;12:e1005622 pubmed publisher
immunohistochemistry; human; 1:50	Yang H, Chen J, Zhang W, Ding Y. Focal adhesion plaque associated cytoskeletons are involved in the invasion and metastasis of human colorectal carcinoma. Cancer Invest. 2010;28:127-34 pubmed publisher
	Broderick R, Cherdyntseva V, Nieminuszczy J, Dragona E, Kyriakaki M, Evmorfopoulou T, et al. Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activity. Nat Commun. 2023;14:2428 pubmed publisher
	Farini A, Tripodi L, Villa C, Strati F, Facoetti A, Baselli G, et al. Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin-deficient mice. EMBO Mol Med. 2023;15:e16244 pubmed publisher
	Francisco A, Li J, Farghli A, Kanke M, Shui B, Munn P, et al. Chemical, Molecular, and Single-nucleus Analysis Reveal Chondroitin Sulfate Proteoglycan Aberrancy in Fibrolamellar Carcinoma. Cancer Res Commun. 2022;2:663-678 pubmed publisher
	Tripodi L, Molinaro D, Fortunato F, Mella C, Cassani B, Torrente Y, et al. Immunoproteasome Inhibition Ameliorates Aged Dystrophic Mouse Muscle Environment. Int J Mol Sci. 2022;23: pubmed publisher
	Romano L, Aw W, Hixson K, Novoselova T, Havener T, Howell S, et al. Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization. Cell Rep. 2022;41:111580 pubmed publisher
	Hsu A, Wang T, Syahirah R, Liu S, Li K, Zhang W, et al. Rora Regulates Neutrophil Migration and Activation in Zebrafish. Front Immunol. 2022;13:756034 pubmed publisher
	Kandasamy P, McClorey G, Shimizu M, Kothari N, Alam R, Iwamoto N, et al. Control of backbone chemistry and chirality boost oligonucleotide splice switching activity. Nucleic Acids Res. 2022;50:5443-5466 pubmed publisher
	Ali M, Magnati S, Panuzzo C, Cilloni D, Saglio G, Pergolizzi B, et al. The Downregulation of Both Giant HERCs, HERC1 and HERC2, Is an Unambiguous Feature of Chronic Myeloid Leukemia, and HERC1 Levels Are Associated with Leukemic Cell Differentiation. J Clin Med. 2022;11: pubmed publisher
	Miller M, McDermitt D, Sauvanet C, Lombardo A, Zaman R, Bretscher A. The RabGAPs EPI64A and EPI64B regulate the apical structure of epithelial cells †. Mol Biol Cell. 2022;33:ar8 pubmed publisher
	Tripodi L, Molinaro D, Farini A, Cadiao G, Villa C, Torrente Y. Flavonoids and Omega3 Prevent Muscle and Cardiac Damage in Duchenne Muscular Dystrophy Animal Model. Cells. 2021;10: pubmed publisher
	Minnelli C, Cianfruglia L, Laudadio E, Mobbili G, Galeazzi R, Armeni T. Effect of Epigallocatechin-3-Gallate on EGFR Signaling and Migration in Non-Small Cell Lung Cancer. Int J Mol Sci. 2021;22: pubmed publisher
	Das S, Surve V, Marathe S, Wad S, Karulkar A, Srinivasan S, et al. IL-9 Abrogates the Metastatic Potential of Breast Cancer by Controlling Extracellular Matrix Remodeling and Cellular Contractility. J Immunol. 2021;206:2740-2752 pubmed publisher
	Farini A, Sitzia C, Villa C, Cassani B, Tripodi L, Legato M, et al. Defective dystrophic thymus determines degenerative changes in skeletal muscle. Nat Commun. 2021;12:2099 pubmed publisher
	Ali M, Panuzzo C, Calabrese C, Maglione A, Piazza R, Cilloni D, et al. The Giant HECT E3 Ubiquitin Ligase HERC1 Is Aberrantly Expressed in Myeloid Related Disorders and It Is a Novel BCR-ABL1 Binding Partner. Cancers (Basel). 2021;13: pubmed publisher
	Vazquez Rodriguez G, Abrahamsson A, Turkina M, Dabrosin C. Lysine in Combination With Estradiol Promote Dissemination of Estrogen Receptor Positive Breast Cancer via Upregulation of U2AF1 and RPN2 Proteins. Front Oncol. 2020;10:598684 pubmed publisher
	Lim K, Han Z, Jeon H, Kach J, Jing E, Weyn Vanhentenryck S, et al. Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression. Nat Commun. 2020;11:3501 pubmed publisher
	Farini A, Villa C, Di Silvestre D, Bella P, Tripodi L, Rossi R, et al. PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy. Front Physiol. 2020;11:403 pubmed publisher
	Obayemi J, Salifu A, Eluu S, Uzonwanne V, Jusu S, Nwazojie C, et al. LHRH-Conjugated Drugs as Targeted Therapeutic Agents for the Specific Targeting and Localized Treatment of Triple Negative Breast Cancer. Sci Rep. 2020;10:8212 pubmed publisher
	Sheykhzadeh S, Luo M, Peng B, White J, Abdalla Y, Tang T, et al. Transferrin-targeted porous silicon nanoparticles reduce glioblastoma cell migration across tight extracellular space. Sci Rep. 2020;10:2320 pubmed publisher
	Park H, Kim D, Kim D, Park J, Koh Y, Yoon S. Truncation of MYH8 tail in AML: a novel prognostic marker with increase cell migration and epithelial-mesenchymal transition utilizing RAF/MAPK pathway. Carcinogenesis. 2020;41:817-827 pubmed publisher
	Watts K, Spiteri M. Connective tissue growth factor expression and induction by transforming growth factor-beta is abrogated by simvastatin via a Rho signaling mechanism. Am J Physiol Lung Cell Mol Physiol. 2004;287:L1323-32 pubmed
	Willey C, Balasubramanian S, Rodríguez Rosas M, Ross R, Kuppuswamy D. Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src. J Mol Cell Cardiol. 2003;35:671-83 pubmed

product information

Product Type :

Antibody

Product Name :

Vinculin Monoclonal Antibody (VLN01)

Catalog # :

MA5-11690

Quantity :

500 µL

Price :

US 496.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate

Applications :

Immunocytochemistry: 2 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL

Species :

Human, Mouse, Non-human primate

Clone :

VLN01

Isotype :

IgG1

Storage :

4° C

Description :

Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.

Immunogen :

Semi-purified vinculin

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL

Aliases :

9430097D22; AA571387; AI462105; AW545629; CMD1W; CMH15; epididymis luminal protein 114; HEL114; metavinculin; meta-vinculin; metavinculin {ECO:0000250; MV; MVCL; RP11-178G16.3; UniProtKB:P18206}; unnamed protein product; Vcl; vcl {ECO:0000250; VIN; vinc; vinc 1; VINC1; Vinculin; vinculin {ECO:0000250