Gli1 antibody | GeneTex GTX27523 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

Gli1 antibody

catalog :

GTX27523

quantity :

50.00μl

price :

289 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 5

Published Application/Species/Dilution	Reference
	Saratsis A, Kambhampati M, Snyder K, Yadavilli S, Devaney J, Harmon B, et al. Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes. Acta Neuropathol. 2014;127:881-95 pubmed publisher
	Colmont C, Benketah A, Reed S, Hawk N, Telford W, Ohyama M, et al. CD200-expressing human basal cell carcinoma cells initiate tumor growth. Proc Natl Acad Sci U S A. 2013;110:1434-9 pubmed publisher
	Stecca B, Ruiz i Altaba A. A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers. EMBO J. 2009;28:663-76 pubmed publisher
	Horn A, Kireva T, Palumbo-Zerr K, Dees C, Tomcik M, Cordazzo C, et al. Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis. Ann Rheum Dis. 2012;71:785-9 pubmed publisher
	Singh R, Cho-Vega J, Davuluri Y, Ma S, Kasbidi F, Milito C, et al. Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma. Cancer Res. 2009;69:2550-8 pubmed publisher

product information

Catalog No :

GTX27523

Product Name :

Gli1 antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary antibody

Size :

50.00μl

List Price :

289 USD

list of Pubmed id :

24297113,22402139,23292936,19244133,19214186

Isotype :

IgG

Product Description :

Rabbit polyclonal to Gli1

CrossReactivity :

Hu, Ms

Background :

Gli was termed by Kinzler et al. (1987) as 'glioma-associated oncogene' amplified in malignant gliomas. Analysis of the cloned gene demonstrates that the gene contains 5 repeats of zinc-finger sequences, which places gli in the family of Kruppel (Kr) zinc finger proteins. Northern analysis reveals that GLI is expressed in embryonal carcinoma cells but not in most adult tissue. GLI has been localized to 12q13-q14.3 by Southern blot analysis. On mouse the gene is located on chromosome 10. In mice, 3 zinc finger transcription factors, Gli1, Gli2 and Gli3, have been implicated in the transduction of Sonic hedgehog (Shh) signal. In papillary epithelium, shh, gli1 and ptc all follow similar expression patterns. Gli1 expression is central and probably sufficient for tumor development in humans.

Immunogen :

Synthetic peptide - corresponding to amino acids 803-818 of the carboxy-terminal region of mouse Gli1.

Specificity :

This antibody is directed against Gli1 from mouse brain. No reaction occurs with human or mouse Gli2 or Gli3.

Buffer :

0.02 M Potassium Phosphate, 0.15 M NaCl, pH 7.2, containing 0.01% sodium azide

Uses :

ELISA, ICC/IF, IHC, IHC-P, WB

General References :

Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.