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product summary
company name :
GeneTex
product type :
antibody
product name :
FGFR1 antibody
catalog :
GTX107393
quantity :
100.00μl
price :
299 USD
clonality :
polyclonal
host :
rabbit
reactivity :
human, mouse
application :
western blot, immunohistochemistry - paraffin section
product information
Catalog No :
GTX107393
Product Name :
FGFR1 antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Product Type :
Primary antibody
Size :
100.00μl
List Price :
299 USD
Isotype :
IgG
Product Description :
Rabbit Polyclonal antibody to FGFR1 (fibroblast growth factor receptor 1)
CrossReactivity :
Hu, Ms
Background :
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq]
Immunogen :
Recombinant protein encompassing a sequence within the center region of human FGFR1. The exact sequence is proprietary.
Buffer :
1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Uses :
IHC-P, WB
Concentration :
1mg/ml
General References :
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Image Legend_4 :
FGFR1 antibody detects FGFR1 protein by Western blot analysis. A. 30 µg SHSY5Y whole cell lysate/extract 7.5 % SDS-PAGE FGFR1 antibody (GTX107393) dilution: 1:1000
Image Legend_5 :
FGFR1 antibody detects FGFR1 protein by Western blot analysis. A. 30 µg 293T whole cell lysate/extract B. 30 µg A431 whole cell lysate/extract C. 30 µg A375 whole cell lysate/extract 7.5 % SDS-PAGE FGFR1 antibody (GTX107393) dilution: 1:1000
Image Legend_6 :
FGFR1 antibody detects FGFR1 protein at cytosol on human breast carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human breast carcinoma. FGFR1 antibody (GTX107393) dilution: 1:500.
Image Legend_7 :
FGFR1 antibody detects FGFR1 protein at cytosol on human colon carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human colon carcinoma. FGFR1 antibody (GTX107393) dilution: 1:500.
Image Legend_8 :
FGFR1 antibody detects FGFR1 protein by western blot analysis. Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with FGFR1 antibody (GTX107393) diluted by 1:1000.
company information
GeneTex
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