PLK1 antibody [N2C2], Internal | GeneTex GTX104302 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

PLK1 antibody [N2C2], Internal

catalog :

GTX104302

quantity :

100.00μl

price :

299 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Liu L, Huang W, Lin R, Lin S, Liang Y. N-Hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colon adenocarcinoma cells in vitro and in vivo. Chem Res Toxicol. 2013;26:1683-91 pubmed publisher

product information

Catalog No :

GTX104302

Product Name :

PLK1 antibody [N2C2], Internal

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary antibody

Size :

100.00μl

List Price :

299 USD

list of Pubmed id :

24127835

Isotype :

IgG

Product Description :

Rabbit Polyclonal antibody to PLK1 (polo-like kinase 1)

CrossReactivity :

Background :

Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS.

Immunogen :

Recombinant protein encompassing a sequence within the center region of human PLK1. The exact sequence is proprietary.

Buffer :

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Uses :

ICC/IF, IHC-P, WB

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.