p300 (catalytic domain) (human), (recombinant) | Enzo Life Sciences BML-SE451-0100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

p300 (catalytic domain) (human), (recombinant)

catalog :

BML-SE451-0100

quantity :

100 µg

citations: 5

Reference
Kerek E, Yoon K, Luo S, Chen J, Valencia R, Julien O, et al. A conserved acetylation switch enables pharmacological control of tubby-like protein stability. J Biol Chem. 2021;296:100073 pubmed publisher
Bartlett E, Bonfiglio J, Prokhorova E, Colby T, Zobel F, Ahel I, et al. Interplay of Histone Marks with Serine ADP-Ribosylation. Cell Rep. 2018;24:3488-3502.e5 pubmed publisher
van den Bosch T, Boichenko A, Leus N, Ourailidou M, Wapenaar H, Rotili D, et al. The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases. Biochem Pharmacol. 2016;102:130-140 pubmed publisher
Sun T, Li X, Zhang P, Chen W, Zhang H, Li D, et al. Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. Nat Commun. 2015;6:7215 pubmed publisher
Milite C, Feoli A, Sasaki K, La Pietra V, Balzano A, Marinelli L, et al. A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach. J Med Chem. 2015;58:2779-98 pubmed publisher

product information

Product ID :

BML-SE451

Catalog Number :

BML-SE451-0100

Product Name :

p300 (catalytic domain) (human), (recombinant)

Product Type :

Protein

Size :

100 µg

list of Pubmed id :

26718586, 26008601, 25730130

Background :

Although originally termed histone acetyltransferases (HATs) for their lysine acetylation activity on histone N-terminal tails, p300 and its paralogue, CBP, have been shown to acetylate a variety of non-histone proteins including p53, DNA polymerase β and nuclear import factors. p300/CBP acetylations play regulatory roles in transcription, DNA repair and replication, the cell cycle, p53 turnover, and nuclear import. In addition to functions which overlap with those of CBP, p300 has a number of unique functions, including a role in the induction of p21Waf1/Cip1 cell cycle inhibitor.

ALTnames :

E1A binding protein p300, Histone acetyltransferase p300

Buffer :

Liquid. In 50mM TRIS/HCl, pH 8.0, containing 0.1mM EDTA, 10% glycerol.

Uses :

Can be used to study p300 kinetics and regulation, for screening for inhibitors or activators and for radiolabeling of proteins or peptides with, for example, [3H]-Acetyl CoA.

Storage :

-80°C