BAG-3 monoclonal antibody (AC-1) | Enzo Life Sciences ALX-803-323-C100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

BAG-3 monoclonal antibody (AC-1)

catalog :

ALX-803-323-C100

quantity :

100 µg

price :

528 USD

clonality :

monoclonal

host :

mouse

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 10

Published Application/Species/Dilution	Reference
immunohistochemistry - paraffin section; rat; 1:100 western blot; rat	Festa M, Del Valle L, Khalili K, Franco R, Scognamiglio G, Graziano V, et al. BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy. Am J Pathol. 2011;178:2504-12 pubmed publisher
	Marsh N, Wareham A, White B, Miskiewicz E, Landry J, MacPhee D. HSPB8 and the Cochaperone BAG3 Are Highly Expressed During the Synthetic Phase of Rat Myometrium Programming During Pregnancy. Biol Reprod. 2015;92:131 pubmed publisher
	Du F, Li S, Wang T, Zhang H, Zong Z, Du Z, et al. Cordyceps sinensis attenuates renal fibrosis and suppresses BAG3 induction in obstructed rat kidney. Am J Transl Res. 2015;7:932-40 pubmed
	Franco R, Scognamiglio G, Salerno V, Sebastiani A, Cennamo G, Ascierto P, et al. Expression of the anti-apoptotic protein BAG3 in human melanomas. J Invest Dermatol. 2012;132:252-4 pubmed publisher
	Basile A, Darbinian N, Kaminski R, White M, Gentilella A, Turco M, et al. Evidence for modulation of BAG3 by polyomavirus JC early protein. J Gen Virol. 2009;90:1629-40 pubmed publisher
	Bruno A, Festa M, Dal Piaz F, Rosati A, Turco M, Giuditta A, et al. Identification of a synaptosome-associated form of BAG3 protein. Cell Cycle. 2008;7:3104-5 pubmed
	Gentilella A, Passiatore G, Deshmane S, Turco M, Khalili K. Activation of BAG3 by Egr-1 in response to FGF-2 in neuroblastoma cells. Oncogene. 2008;27:5011-8 pubmed publisher
	Staibano S, Mascolo M, Di Benedetto M, Vecchione M, Ilardi G, Di Lorenzo G, et al. BAG3 protein delocalisation in prostate carcinoma. Tumour Biol. 2010;31:461-9 pubmed publisher
	Chiappetta G, Basile A, Arra C, Califano D, Pasquinelli R, Barbieri A, et al. BAG3 down-modulation reduces anaplastic thyroid tumor growth by enhancing proteasome-mediated degradation of BRAF protein. J Clin Endocrinol Metab. 2012;97:E115-20 pubmed publisher
	Franceschelli S, Rosati A, Lerose R, De Nicola S, Turco M, Pascale M. Bag3 gene expression is regulated by heat shock factor 1. J Cell Physiol. 2008;215:575-7 pubmed publisher

product information

Product ID :

ALX-803-323

Catalog Number :

ALX-803-323-C100

Product Name :

BAG-3 monoclonal antibody (AC-1)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

List Price (USD) :

528 USD

list of Pubmed id :

26175854, 25904010, 21850027, 20535599, 19282432, 18818513, 18469860, 18286539

Image Legend 4 :

Figure 1: Indirect immunofluorescence of BAG-3 from NPA (human thyroid carcinoma) cells using MAb to BAG-3 (AC-1) (Prod. No. ALX-803-323) and secondary antibody rhodamine-conjugated anti-mouse IgG.A) Negative control; Mouse IgG at 3µg/mlB) MAb to BAG-3 (AC-1) at 3µg/ml

Clone :

AC-1

Isotype :

IgG1

SPECIES REACTIVITY :

Human, Mouse, Rat

Background :

BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-3 (CAIR-1; Bis) forms a complex with HSC70 and assists in polypeptide folding. In addition, this complex can mediate protein delivery to proteasome and is able to downregulate apoptosis by interfering with cytochrome c release, apoptosome assembly and other events. In human cancer cell lines, BAG-3 expression sustains cell survival and underlies resistance to therapy through downmodulation of apoptosis.

ALTnames :

Docking protein CAIR-1, Bcl-2-binding athanogene-3

Immunogen :

Synthetic peptide corresponding to aa 18-33 (D18RDPLPPGWEIKIDPQ33) of N-terminal human BAG-3 (Bcl-2-binding athanogene-3).

Buffer :

Liquid. In PBS containing 0.02% sodium azide.

Application Summary :

ELISA, ICC, IHC, IP, WB

Storage :

-20°C