Shc monoclonal antibody (11F6) | Enzo Life Sciences ADI-905-665-100 product information

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product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Shc monoclonal antibody (11F6)

catalog :

ADI-905-665-100

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

11F6

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

product information

Product ID :

ADI-905-665

Catalog Number :

ADI-905-665-100

Product Name :

Shc monoclonal antibody (11F6)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

Clone :

11F6

Isotype :

IgG1

SPECIES REACTIVITY :

Human, Mouse

Background :

The Src homology 2 domain containing (Shc) adaptor protein links growth factor, cytokine, and antigen receptor stimulation to the Ras signaling pathway, and plays a critical role in insulin signaling, tumorigenesis, and hematopoietic cell growth and differentiation. Structurally, Shc is composed of an N-terminal phosphotyrosine binding (PTB) domain, a medial CH1 domain, and a C-terminal SH2 domain. Upon binding to activate cell-surface receptors, Shc is phosphorylated at three tyrosine residues (Tyr239, Tyr240, Tyr317) triggering recognition of Shc by SH2-containing proteins such as Grb2.

ALTnames :

Src homology 2 domain containing

Immunogen :

Synthetic peptide corresponding to the sequence near the C-terminus of Shc.

Buffer :

Lyophilized from 1ml of 2x PBS containing 0.09% sodium azide, PEG, and sucrose.

Uses :

Detects bands of ~46kDa, ~52kDa and ~66kDa by Western blot.

Application Summary :

ELISA, ICC, IHC, WB

Storage :

-20°C