Complement C4a des Arg (human), ELISA kit | Enzo Life Sciences ADI-900-059 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

Complement C4a des Arg (human), ELISA kit

catalog :

ADI-900-059

quantity :

96 wells

citations: 2

Reference
Joseph K, Tuscano T, Kaplan A. Studies of the mechanisms of bradykinin generation in hereditary angioedema plasma. Ann Allergy Asthma Immunol. 2008;101:279-86 pubmed publisher
Abdul Salam V, Paul G, Ali J, Gibbs S, Rahman D, Taylor G, et al. Identification of plasma protein biomarkers associated with idiopathic pulmonary arterial hypertension. Proteomics. 2006;6:2286-94 pubmed

product information

Product ID :

ADI-900-059

Catalog Number :

ADI-900-059

Product Name :

Complement C4a des Arg (human), ELISA kit

Product Type :

Kit

Size :

96 wells

list of Pubmed id :

18814451, 16493708

Product Description :

The Complement C4a des Arg (human), EIA kit is a colorimetric competitive enzyme immunoassay kit with results in 3 hours. Absorbance is read at 405 nm. The kit comes with ready-to-use liquid color-coded reagents that reduce error in the lab and the necessesary sample preparation buffers.

SPECIES REACTIVITY :

Human

Background :

Activation of the complement cascade is initiated by multiple pathways, including C1q binding of antigen-antibody complexes on pathogens (classical pathway), binding of serum lectin to pathogen-unique mannose residue patterns (MBL pathway), or the spontaneous hydrolysis of C3 and subsequent processing to C3 convertase (alternative pathway). C3a and C4a are two complement cleavage products of 77- and 76-amino acid residues, respectively, that are liberated into the bloodstream and processed to their more stable metabolites C3a des Arg and C4a des Arg. Although both fragments have anaphylactic properties, C3a is considered a more potent stimulator of smooth muscle cell contraction, histamine release, and inflammation than C4a. Complement activation is associated with sepsis, respiratory distress syndrome, multi-organ failure, and transplant organ rejection.

Uses :

For the quantitative determination of Complement C4a des arg in human EDTA plasma.

Application Summary :

ELISA, Colorimetric detection