15(S)-HETE ELISA kit | Enzo Life Sciences ADI-900-051 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

15(S)-HETE ELISA kit

catalog :

ADI-900-051

quantity :

96 wells

citations: 10

Reference
Sun L, Xu Y, Han J, Liang H, Wang N, Cheng Y. 12/15-Lipoxygenase metabolites of arachidonic acid activate PPARÎ³: a possible neuroprotective effect in ischemic brain. J Lipid Res. 2015;56:502-14 pubmed publisher
Galet C, Gollapudi K, Stepanian S, Byrd J, Henning S, Grogan T, et al. Effect of a low-fat fish oil diet on proinflammatory eicosanoids and cell-cycle progression score in men undergoing radical prostatectomy. Cancer Prev Res (Phila). 2014;7:97-104 pubmed publisher
Blazevic T, Schwaiberger A, Schreiner C, Schachner D, Schaible A, Grojer C, et al. 12/15-lipoxygenase contributes to platelet-derived growth factor-induced activation of signal transducer and activator of transcription 3. J Biol Chem. 2013;288:35592-603 pubmed publisher
Li Q, Cheon Y, Kannan A, Shanker S, Bagchi I, Bagchi M. A novel pathway involving progesterone receptor, 12/15-lipoxygenase-derived eicosanoids, and peroxisome proliferator-activated receptor gamma regulates implantation in mice. J Biol Chem. 2004;279:11570-81 pubmed
Kowalski M, Ptasinska A, Bienkiewicz B, Pawliczak R, Dubuske L. Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. J Allergy Clin Immunol. 2003;112:505-12 pubmed
Wu J, Xia H, Tu S, Fan D, Lin M, Kung H, et al. 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer. Carcinogenesis. 2003;24:243-7 pubmed
Shureiqi I, Xu X, Chen D, Lotan R, Morris J, Fischer S, et al. Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression. Cancer Res. 2001;61:4879-84 pubmed
Shureiqi I, Chen D, Lotan R, Yang P, Newman R, Fischer S, et al. 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. Cancer Res. 2000;60:6846-50 pubmed
Profita M, Sala A, Riccobono L, Pace E, Paterno A, Zarini S, et al. 15(S)-HETE modulates LTB(4) production and neutrophil chemotaxis in chronic bronchitis. Am J Physiol Cell Physiol. 2000;279:C1249-58 pubmed
Navab M, Hama S, Cooke C, Anantharamaiah G, Chaddha M, Jin L, et al. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1. J Lipid Res. 2000;41:1481-94 pubmed

product information

Product ID :

ADI-900-051

Catalog Number :

ADI-900-051

Product Name :

15(S)-HETE ELISA kit

Product Type :

Kit

Size :

96 wells

list of Pubmed id :

25605873, 24169960, 24165129, 14688261, 13679808, 12584173, 11406566, 11156377, 11003605, 10974056

Product Description :

The 15(S)-HETE EIA kit is a colorimetric competitive enzyme immunoassay kit with results overnight + 1 hour. Absorbance is read at 405 nm.

SPECIES REACTIVITY :

Species independent

Background :

HETEs are byproducts generated by the metabolism of arachidonic acid by lipoxygenases. 12(S)-HETE is the stereospecific hydroxy product from the reduction of 12(S)-hydroperoxy tetraenoic eicosatetraenoic acid [12(S)-HpETE], which itself is a 12-lipoxygenase metabolite of arachidonic acid. 12(S)-HETE is chemotactic and chemokinetic for polymorphonuclear leukocytes and vascular smooth muscle cells. It also acts as a second messenger in angiotensin-II induced aldosterone production. 15-hydroxyeicosatetraenoic acid [15(S)-HETE] is the major hydroxy derivative of arachidonic acid when acted upon by 15-lipoxygenase. It is also the primary monohydroxy acid synthesized by the lipoxygenase activity of Cyclooxygenase-1 upon linoleic acid. 15(S)-HETE acts as a paracrine regulator of smooth muscle and lung neutrophil recruitment, and elevated levels of 15(S)-HETE are associated with asthma, rhinitis, chronic paranasal sinusitis and rheumatoid arthritis.

ALTnames :

15(S)-hydroperoxy tetraenoic eicosatetraenoic acid

Uses :

For the quantitative determination of 15(S)-HETE in culture supernatants, plasma, serum, and urine from any species.

Application Summary :

ELISA, Colorimetric detection