SUR2B Antibody, clone N323A/31 | EMD Millipore MABN511 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SUR2B Antibody, clone N323A/31

catalog :

MABN511

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

N323/A31

The same clone is also sold as:

Abcam: ab174631

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

Catalog Number :

MABN511

Subcategory :

Neuroscience

Product Name :

Anti-SUR2B Antibody, clone N323A/31

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q63563-2

Host Name :

Mouse

Antigen :

SUR2B

Clone :

N323/A31

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-SUR2B Antibody, clone N323A/31

Cross Reactivity :

Human;Mouse;Rat

Background :

Sulfonylurea receptor 2 (Sur2), also known as ATP-binding cassette sub-family C member 9 (ABCC9), belongs to the ATP-binding cassette transporter (ABC transporter) superfamily. Sur2 is a subunit of ATP-sensitive potassium channels (KATP). The potassium channel, inwardly rectifying subfamily J member 11 (KCNJ11) interacts with Sur2 in the formation of cardiac and smooth muscle-type KATP channels, where Sur2 is required for activation and regulation of the channel. Sur2 is expressed at high levels in heart, skeletal muscle and ovary, and at moderate levels in brain, tongue and pancreatic islets. Expression in other tissue is at low levels. Defects in KCNJ11 are the cause of familial hyperinsulinemic hypoglycemia type 2 (HHF2), diabetes mellitus permanent neonatal (PNDM), as well as transient neonatal diabetes mellitus type 3 (TNDM3). Sur2B is an alternatively spliced isoforms of Sur2 (Sur2A), having differences in the amino acid sequence (1504-1545).

ALT Names :

ATP-binding cassette sub-family C member 9;Sulfonylurea receptor 2

Immunogen :

Recombinant protein corresponding to the cytoplasmic domain of the cleaved form of rat SUR2.

Specificity :

This antibody recognizes the cytoplasmic domain of the cleaved form of SUR2B. This antibody may cross react with SUR1 based upon 75% sequence homology.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt