Cholesterol-24 Hydroxylase Antibody, clone1A7 | EMD Millipore MAB2259 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cholesterol-24 Hydroxylase Antibody, clone1A7

catalog :

MAB2259

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1A7

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 3	Huang Y, Lin C, Liao H, Liu C, Chen Y, Chiu W, et al. Cholesterol overload induces apoptosis in SH-SY5Y human neuroblastoma cells through the up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling. Neuroscience. 2016;328:201-9 pubmed publisher

product information

Catalog Number :

MAB2259

Subcategory :

Neuroscience

Product Name :

Anti-Cholesterol-24 Hydroxylase Antibody, clone1A7

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9Y6A2

Host Name :

Mouse

Antigen :

Cholesterol-24 Hydroxylase

Clone :

1A7

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Cholesterol-24 Hydroxylase Antibody, clone1A7

Cross Reactivity :

Mouse;Human;Rat;Rabbit

Background :

In enzymology, a cholesterol 24-hydroxylase (EC 1.14.13.98) is an enzyme that catalyzes the chemical reaction: cholesterol + NADPH + H+ + O2 -- (24S)-24-hydroxycholesterol + NADP+ + H2O. Cholesterol 24-hydroxylase, a cytochrome P450 (CYP46A1), is expressed at 100-fold higher levels in the brain than in the liver. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. Studies indicate that cholesterol 24-hydroxylase constitutes a major tissue-specific pathway for cholesterol turnover in the brain (Lund, 2003).

ALT Names :

Cytochrome P450 46A1;cholesterol 24-hydroxylase;cytochrome P450, family 46;cytochrome P450, family 46, subfamily A, polypeptide 1;cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)

Immunogen :

His-tagged recombinant protein corresponding to human cholesterol-24 hydroxylase.

Specificity :

This antibody recognizes cholesterol-24 hydroxylase.

Package Size :

100 μg

Uses :

Western Blotting;Immunoprecipitation;Immunocytochemistry;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt