MMP-13 Antibody, clone LIPCO IID1 | EMD Millipore MAB13426 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MMP-13 Antibody, clone LIPCO IID1

catalog :

MAB13426

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

LIPCO IID1

The same clone is also sold as:

LifeSpan Biosciences: LS-C85296
Invitrogen: MA5-14247

reactivity :

mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 13

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:200; loading ...; fig 4c	Chang S, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway. Nat Commun. 2019;10:1442 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:500; fig 4	Aini H, Itaka K, Fujisawa A, Uchida H, Uchida S, Fukushima S, et al. Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment. Sci Rep. 2016;6:18743 pubmed publisher
western blot; rat	PÃ©rez Vargas J, Zarco N, Vergara P, Shibayama M, Segovia J, Tsutsumi V, et al. l-Theanine prevents carbon tetrachloride-induced liver fibrosis via inhibition of nuclear factor ÎºB and down-regulation of transforming growth factor Î² and connective tissue growth factor. Hum Exp Toxicol. 2016;35:135-46 pubmed publisher
	Murahashi Y, Yano F, Kobayashi H, Makii Y, Iba K, Yamashita T, et al. Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis. Sci Rep. 2018;8:16475 pubmed publisher
	Aldaba Muruato L, Moreno M, Hernández Mercado E, Shibayama M, Muriel P. Secondary biliary cirrhosis in the rat is prevented by decreasing NF-?B nuclear translocation and TGF-? expression using allopurinol, an inhibitor of xanthine oxidase. Can J Physiol Pharmacol. 2012;90:1469-78 pubmed publisher
	Arauz J, Moreno M, Cortes Reynosa P, Salazar E, Muriel P. Coffee attenuates fibrosis by decreasing the expression of TGF-? and CTGF in a murine model of liver damage. J Appl Toxicol. 2013;33:970-9 pubmed publisher
	Aldaba Muruato L, Moreno M, Shibayama M, Tsutsumi V, Muriel P. Protective effects of allopurinol against acute liver damage and cirrhosis induced by carbon tetrachloride: modulation of NF-?B, cytokine production and oxidative stress. Biochim Biophys Acta. 2012;1820:65-75 pubmed publisher
	Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley C, Overall C. Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis. J Biol Chem. 2011;286:34271-85 pubmed publisher
	Chávez E, Castro Sanchez L, Shibayama M, Tsutsumi V, Perez Salazar E, Moreno M, et al. Effects of acetyl salycilic acid and ibuprofen in chronic liver damage induced by CCl4. J Appl Toxicol. 2012;32:51-9 pubmed publisher
	Papazoglou E, Sunkari C, Neidrauer M, Klement J, Uitto J. Noninvasive assessment of UV-induced skin damage: comparison of optical measurements to histology and MMP expression. Photochem Photobiol. 2010;86:138-45 pubmed publisher
	Su J, Yu J, Ren T, Zhang W, Zhang Y, Liu X, et al. Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritis. Mol Cell Biochem. 2009;330:141-52 pubmed publisher
	Han Y, Yan C, Zhou L, Qin L, Tsukamoto H. A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix. J Biol Chem. 2007;282:12928-39 pubmed
	Mesa C, Mirza M, Mitsutake N, Sartor M, Medvedovic M, Tomlinson C, et al. Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling. Cancer Res. 2006;66:6521-9 pubmed

product information

Catalog Number :

MAB13426

Subcategory :

Cell Structure

Product Name :

Anti-MMP-13 Antibody, clone LIPCO IID1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P45452

Host Name :

Mouse

Antigen :

MMP-13

Clone :

LIPCO IID1

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-MMP-13 Antibody, clone LIPCO IID1

Cross Reactivity :

Mouse;Rat

ALT Names :

Collagenase-3

Immunogen :

Rat MMP-13 from BC-1 cells.

Specificity :

It recognizes proteins of ~60 kDa and ~48 kDa which are identified as pro (latent) and activate forms of matrix metalloproteinase-13 (MMP-13; also known as Collagenase-3). Antibody shows no cross-reactivity with the pro and active forms of other MMPs. Human collagenase-3 (MMP13) is a recently identified member of the matrix metalloproteinase (MMP) family that is expressed in breast carcinomas and in articular cartilage from arthritic patients. The MMP-13 gene has been isolated and characterized. This gene is composed of 10 exons and 9 introns and spans over 12.5 kb. The overall organization of the collagenase-3 gene is similar to that of other MMP genes clustered at chromosome 11q22, including fibroblast collagenase (MMP-1), matrilysin (MMP-7), and macrophage metalloelastase (MMP-12), but is more distantly related to genes coding for stromelysin-3 (MMP-11), gelatinase-A (MMP-2), and gelatinase-B (MMP-9), which map outside of this gene cluster. Cellular Localization: Cytoplasmic

Package Size :

100 µg

Uses :

Western Blotting

Storage :

Maintain at 2-8°C in undiluted aliquots for up to 12 months.