Milli-Mark™ Anti-GSK3-FITC Antibody, clone 4G-1E | EMD Millipore FCMAB386F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark™ Anti-GSK3-FITC Antibody, clone 4G-1E

catalog :

FCMAB386F

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

4G-1E

The same clone is also sold as:

Invitrogen: MA3-038

reactivity :

human, mouse

application :

flow cytometry

citations: 2

Reference
Loi M, Becherini P, Emionite L, Giacomini A, Cossu I, Destefanis E, et al. sTRAIL coupled to liposomes improves its pharmacokinetic profile and overcomes neuroblastoma tumour resistance in combination with Bortezomib. J Control Release. 2014;192:157-66 pubmed publisher
MacDonald B, Semenov M, Huang H, He X. Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6. PLoS ONE. 2011;6:e23537 pubmed publisher

product information

Catalog Number :

FCMAB386F

Subcategory :

Cell Signaling

Product Name :

Milli-Mark™ Anti-GSK3-FITC Antibody, clone 4G-1E

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P49840

Host Name :

Mouse

Antigen :

GSK3-FITC

Clone :

4G-1E

Conjugate :

FITC

Isotype :

IgG1

Product Description :

Milli-Mark™ Anti-GSK3-FITC Antibody, clone 4G-1E

Cross Reactivity :

Human

Background :

Glycogen synthase kinase-3 (GSK-3), a multifunctional serine/threonine kinase, is a key regulator of numerous signaling pathways. Two isoforms of GSK-3 are reported in mammals: a 51 kDa GSK-3a and a 47 kDa GSK-3b. These two isoforms exhibit about 98% homology in their kinase domains, but share only about 36% identity in the last 76 C-terminal amino acid residues. GSK-3a contains a glycine-rich extension at its N-terminus. A minor (~15% of total) splice variant of GSK-3b, GSK-3b2, has also been identified, which contains a 13-residue insert within the kinase domain. It exhibits reduced kinase activity towards tau protein compared with ‘unspliced’ GSK-3b. GSK-3b2 is localized primarily to neuronal cell bodies, unlike unspliced GSK-3b that is also found in neuronal processes. GSK-3b plays a key inhibitory role in the Wnt signaling pathway. Wnt genes encode a large family of secreted, cysteine-rich proteins that are important in development and in maintenance of adult tissues. Abnormalities in Wnt signaling are reported to promote both human degenerative diseases and cancer.

ALT Names :

GSK-3 alpha;glycogen synthase kinase 3 alpha

Immunogen :

Synthetic peptide derived from a region of the catalytic domain (between subdomain VII and VIII) of the Drosophila GSK3/shaggy enzyme, coupled to ovalbumin.

Specificity :

Antibody recognizes GSK3.

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.