Tau phospho Serine 262 Antibody | EMD Millipore AB9656 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tau phospho Serine 262 Antibody

catalog :

AB9656

quantity :

100 µL

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

citations: 1

Reference
Müller M, Lutter D, Püschel A. Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity. J Cell Sci. 2010;123:286-94 pubmed publisher

product information

Catalog Number :

AB9656

Subcategory :

Neuroscience

Product Name :

Anti-Tau phospho Serine 262 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P10636

Host Name :

Rabbit

Antigen :

Tau phospho Serine 262

Conjugate :

Affinity Purified

Product Description :

Anti-Tau phospho Serine 262 Antibody

Cross Reactivity :

Human

Background :

Tau is a neuronal microtubule-associated protein found predominantly on axons and functions to promote tubulin polymerization and stabilize microtubules. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylated Tau is also found in neurofibrillary lesions in a range of other central nervous system disorders. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II (CK2), phosphorylate Tau. Serine 262 can be phosphorylated by GSK-3beta, PKA, CamKII, MARK and has been found to be a major site in AD brain.

Immunogen :

Synthetic peptide of amino acids surrounding the phosphoSerine 262 site of human Tau.

Specificity :

Tau phosphoSerine 262. The antibody recognizes Tau pSerine 262 in samples of recombinant human Tau treated with PKA for 45 minutes. The reactivity of the antibody is blocked with the pSerine 262 peptide but not the non-phosphopeptide or a generic phosphoSerine-containing peptide.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.