TIMP-3 Antibody, CT | EMD Millipore AB6000 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TIMP-3 Antibody, CT

catalog :

AB6000

quantity :

100 μg

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, dog, cow

application :

western blot, immunocytochemistry

citations: 3

Reference
Zhang H, Gao L, Anandhakumar J, Gross D. Uncoupling transcription from covalent histone modification. PLoS Genet. 2014;10:e1004202 pubmed publisher
Strukov Y, Sural T, Kuroda M, Sedat J. Evidence of activity-specific, radial organization of mitotic chromosomes in Drosophila. PLoS Biol. 2011;9:e1000574 pubmed publisher
Almstrup K, Nielsen J, Mlynarska O, Jansen M, Jørgensen A, Skakkebæk N, et al. Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells. Br J Cancer. 2010;103:1269-76 pubmed publisher

product information

Catalog Number :

AB6000

Subcategory :

Cell Structure

Product Name :

Anti-TIMP-3 Antibody, CT

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P35625

Host Name :

Rabbit

Antigen :

TIMP-3

Conjugate :

Affinity Purified

Product Description :

Anti-TIMP-3 Antibody, CT

Cross Reactivity :

Human;Rat;Pig;Canine;Monkey;Primate;Horse;Bovine

Background :

Tissue inhibitor of metalloproteinases 3 (TIMP-3) is a member of the TIMP family. The TIMPs are so named because they are slow, tight binding endogenous inhibitors of the Matrix Metalloproteinases (MMPs). The four TIMPs have different inhibition constants for the different MMPs studied. TIMPs have been shown to have activity against the ADAMs family of proteinases. TIMP-3 is an efficient "sheddase" inhibitor, inhibiting ADAM-17 (TACE) at the low nanomolar levels seen with MMP inhibition. The other ADAMs proteinases have not yet been assayed for TIMP inhibition, but TIMP-2 seems to be much less active on ADAM-17 than isTIMP-3. TIMP-3 is thought to be constitutively produced by many cell types and is inducible in others. The TIMP-3 localization differs from the other 3 TIMPs, and is thought to be primarily deposited into the extracellular matrix.

ALT Names :

MIG-5;TIMP metallopeptidase inhibitor 3;Tissue inhibitor of metalloproteinases 3

Immunogen :

KLH-conjugated linear peptide corresponding to human TIMP-3 at the C-terminus.

Specificity :

The antibody recognizes TIMP-3 at the C-terminus. Does not appear to cross react with TIMP-1 or TIMP-2.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt